M.S. and A.A.V. contributed equally to this work.
Paradoxical opsin expressing cells in the inner retina that are augmented following retinal degeneration
Article first published online: 16 APR 2007
European Journal of Neuroscience
Volume 25, Issue 8, pages 2296–2306, April 2007
How to Cite
Semo, M., Vugler, A. A. and Jeffery, G. (2007), Paradoxical opsin expressing cells in the inner retina that are augmented following retinal degeneration. European Journal of Neuroscience, 25: 2296–2306. doi: 10.1111/j.1460-9568.2007.05461.x
- Issue published online: 16 APR 2007
- Article first published online: 16 APR 2007
- Received 17 November 2006, revised 5 February 2007, accepted 5 February 2007
- retinitis pigmentosa
Here we reveal a population of cells that express cone photoreceptor opsins that are located in the inner retina, distant from outer retinal photoreceptors. These cells are present in rodents and human. They also express a range of key proteins critical in the cone phototransduction cascade and make contact with other retinal neurons. Their opsins are not generally confined to cellular specialized regions but are present throughout the plasma membrane, although their nuclear configurations are similar to those of outer retinal cones. This population is distinct from the ganglion cells that contain melanopsin and which are known to be inner retinal irradiance detectors regulating circadian behaviour. Surprisingly, the size of the population of short wavelength opsin positive cells in the ganglion cell layer is plastic. In normal animals their number declines with age. However, their numbers increase significantly in response to outer retinal photoreceptor loss, probably by drawing on a pool of inner retinal cells that express cone specific markers, but not opsins.