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References

  • Barberis, A., Lu, C., Vicini, S. & Mozrzymas, J.W. (2005) Developmental changes of GABA synaptic transient in cerebellar granule cells. Mol. Pharmacol., 67, 12211228.
  • Bohme, I., Rabe, H. & Luddens, H. (2004) Four amino acids in the alpha subunits determine the gamma-aminobutyric acid sensitivities of GABAA receptor subtypes. J. Biol. Chem., 279, 35 19335 200.
  • Browne, S.H., Kang, J., Akk, G., Chiang, L.W., Schulman, H., Huguenard, J.R. & Prince, D.A. (2001) Kinetic and pharmacological properties of GABAA receptors in single thalamic neurons and GABAA subunit expression. J. Neurophysiol., 86, 23122322.
  • Chang, Y., Ghansah, E., Chen, Y., Ye, J., Weiss, D.S. & Chang, Y. (2002) Desensitization mechanism of GABA receptors revealed by single oocyte binding and receptor function. J. Neurosci., 22, 79827990.
  • Chen, C. & Okayama, H. (1987) High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol., 7, 27452752.
  • Clements, J.D. (1996) Transmitter timecourse in the synaptic cleft: its role in central synaptic function. Trends Neurosci., 19, 163171.
  • Colquhoun, D. (1998) Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors. Br. J. Pharmacol., 125, 924947.
  • Colquhoun, D. & Sakmann, B. (1985) Fast events in single channel currents activated by acetylcholine and its analogues at the frog muscle end-plate. J. Physiol., 369, 501557.
  • Colquhoun, D. & Sigworth, F.J. (1995) Fitting and statistical analysis of single-channel records. In Sakmann, B. & Neher, E. (Eds), Single-Channel Recording, 2nd Edn. Plenum Press, New York, pp. 231243.
  • Fritschy, J.M. & Brunig, I. (2003) Formation and plasticity of GABAergic synapses: physiological mechanisms and pathophysiological implications. Pharmacol. Ther., 98, 299323.
  • Gao, B., Fritschy, J.M., Benke, D. & Mohler, H. (1993) Neuron-specific expression of GABAA-receptor subtypes: differential association of the alpha 1- and alpha 3-subunits with serotonergic and GABAergic neurons. Neuroscience, 54, 881892.
  • Gingrich, K.J., Roberts, W.A. & Kass, R.S. (1995) Dependence of the GABAA receptor gating kinetics on the alpha-subunit isoform: implications for structure-function relations and synaptic transmission. J. Physiol., 489, 529543.
  • Hutcheon, B., Morley, P. & Poulter, M.O. (2000) Developmental change in GABAA receptor desensitization kinetics and its role in synapse function in rat cortical neurons. J. Physiol., 522, 317.
  • Jonas, P. (1995) Fast application of agonists to isolated membrane patches. In Sakmann, B. & Neher, E. (Eds), Single-Channel Recording, 2nd Edn. Plenum Press, New York, pp. 231243.
  • Jones, M.V. & Westbrook, G.L. (1995) Desensitized states prolong GABAA channel responses to brief agonist pulses. Neuron, 15, 181191.
  • Jones, M.V., Sahara, Y., Dzubay, J.A. & Westbrook, G.L. (1998) Defining affinity with the GABAA receptor. J. Neurosci., 18, 85908604.
  • Lavoie, A.M., Tingey, J.J., Harrison, N.L., Pritchett, D.B. & Twyman, R.E. (1997) Activation and deactivation rates of recombinant GABAA receptor channels are dependent on alpha-subunit isoform. Biophys. J., 73, 25182526.
  • Macdonald, R.L., Rogers, C.J. & Twyman, R.E. (1989) Kinetic properties of the GABAA receptor main conductance state of mouse spinal cord neurones in culture. J. Physiol., 410, 479499.
  • Maconochie, D.J., Zempel, J.M. & Steinbach, J.H. (1994) How quickly can GABAA receptors open? Neuron, 12, 6171.
  • McClellan, A.M. & Twyman, R.E. (1999) Receptor system response kinetics reveal functional subtypes of native murine and recombinant human GABAA receptors. J. Physiol., 515, 711727.
  • Mozrzymas, J.W. (2004) Dynamism of GABAA receptor activation shapes the ‘personality’ of inhibitory synapses. Neuropharmacology, 47, 945960.
  • Mozrzymas, J.W. & Cherubini, E. (1998) Changes in intracellular calcium concentration affect desensitization of GABAA receptors in acutely dissociated P2–P6 rat hippocampal neurons. J. Neurophysiol., 79, 13211328.
  • Mozrzymas, J.W., Barberis, A., Mercik, K. & Zarnowska, E.D. (2003a) Binding sites, singly bound states, and conformation coupling shape GABA-evoked currents. J. Neurophysiol., 89, 871883.
  • Mozrzymas, J.W., Zarnowska, E.D., Pytel, M. & Mercik, K. (2003b) Modulation of GABA(A) receptors by hydrogen ions reveals synaptic GABA transient and a crucial role of the desensitization process. J. Neurosci., 23, 79817992.
  • Ortinski, P.I., Lu, C., Takagaki, K., Fu, Z. & Vicini, S. (2004) Expression of distinct alpha subunits of GABAA receptor regulates inhibitory synaptic strength. J. Neurophysiol., 92, 17181727.
  • Overstreet, L.S., Jones, M.V. & Westbrook, G.L. (2000) Slow desensitization regulates the availability of synaptic GABAA receptors. J. Neurosci., 20, 79147921.
  • Pirker, S., Schwarzer, C., Wieselthaler, A., Sieghart, W. & Sperk, G. (2000) GABAA receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience, 101, 815850.
  • Rudolph, U. & Mohler, H. (2004) Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics. Annu. Rev. Pharmacol. Toxicol., 44, 475498.
  • Rusch, D. & Forman, S.A. (2005) Classic benzodiazepines modulate the open-close equilibrium in alpha1beta2gamma2L gamma-aminobutyric acid type A receptors. Anesthesiology, 102, 783792.
  • Scheller, M. & Forman, S.A. (2002) Coupled and uncoupled gating and desensitization effects by pore domain mutations in GABAA receptors. J. Neurosci., 22, 84118421.
  • Twyman, R.E., Rogers, C.J. & Macdonald, R.L. (1990) Intraburst kinetic properties of the GABAA receptor main conductance state of mouse spinal cord neurones in culture. J. Physiol., 423, 193220.
  • Verdoorn, T.A. (1994) Formation of heteromeric gamma-aminobutyric acid type A receptors containing two different alpha subunits. Mol. Pharmacol., 45, 475480.
  • Vicini, S. & Ortinski, P. (2004) Genetic manipulations of GABAA receptor in mice make inhibition exciting. Pharmacol. Ther., 103, 109120.
  • Whiting, P.J. (2003) GABAA receptor subtypes in the brain: a paradigm for CNS drug discovery? Drug Discov. Today, 8, 445450.
  • Yee, B.K., Keist, R., Von Boehmer, L., Studer, R., Benke, D., Hagenbuch, N., Dong, Y., Malenka, R.C., Fritschy, J.M., Bluethmann, H., Feldon, J., Mohler, H. & Rudolph, U. (2005) A schizophrenia-related sensorimotor deficit links a3-containing GABAA receptors to a dopamine hyperfunction. Proc. Natl Acad. Sci. U.S.A., 102, 17 15417 159.