CD4+CD25 effector T-cells inhibit hippocampal long-term potentiation in vitro

Authors

  • Gil M. Lewitus,

    1. Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
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  • Julia Zhu,

    1. Laboratory of Neuro-immune Regulation, University of Nebraska Medical Center, Omaha NE 68198-5800, USA
    2. Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha NE 68198-5800, USA
    3. Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha NE 68198-5800, USA
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  • Huangui Xiong,

    1. Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha NE 68198-5800, USA
    2. Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha NE 68198-5800, USA
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  • Richard Hallworth,

    1. Department of Biomedical Sciences, Creighton University, Omaha NE 68135, USA
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  • Jonathan Kipnis

    1. Laboratory of Neuro-immune Regulation, University of Nebraska Medical Center, Omaha NE 68198-5800, USA
    2. Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha NE 68198-5800, USA
    3. Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha NE 68198-5800, USA
    4. Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha NE 68198-5800, USA
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    • *

      Present address: Department of Neuroscience, University of Virginia, Charlottesville, VA, 22908, USA


Dr J. Kipnis, at *present address below.
E-mail: jk3pv@virginia.edu

Abstract

During neuroinflammation T-cells invade the CNS, and may lead to the development and progression of several pathologies, of which multiple sclerosis is the most common. In these pathologies neuroinflammation is often associated with cognitive dysfunction. Using mouse hippocampal slices, we show here that CD4+CD25 T-cells inhibit long-term potentiation (LTP) induced by high-frequency stimulation. The T-cell-mediated inhibition of LTP can be prevented by blockade of γ-aminobutyric acid (GABA)A receptors. These findings provide additional insight into the multiple functions of T-cells in CNS pathologies.

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