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References

  • Aho, M., Erkola, O., Kallio, A., Scheinin, H. & Korttila, K. (1992) Dexmedetomidine infusion for maintenance of anesthesia in patients undergoing abdominal hysterectomy. Anesth. Analg., 75, 940946.
  • Anzai, Y. & Nishikawa, T. (1995) Thoracic epidural clonidine and morphine for postoperative pain relief. Can. J. Anaesth., 42, 292297.
  • Asano, T., Dohi, S., Ohta, S., Shimonaka, H. & Iida, H. (2000) Antinociception by epidural and systemic alpha(2)-adrenoceptor agonists and their binding affinity in rat spinal cord and brain. Anesth. Analg., 90, 400407.
  • Baba, H., Shimoji, K. & Yoshimura, M. (2000) Norepinephrine facilitates inhibitory transmission in substantia gelatinosa of adult rat spinal cord (part 1): effects on axon terminals of GABAergic and glycinergic neurons. Anesthesiology, 92, 473484.
  • But, A.K., Ozgul, U., Erdil, F., Gulhas, N., Toprak, H.I., Durmus, M. & Ersoy, M.O. (2006) The effects of pre-operative dexmedetomidine infusion on hemodynamics in patients with pulmonary hypertension undergoing mitral valve replacement surgery. Acta Anaesthesiol. Scand., 50, 12071212.
  • Bylund, D.B. (1988) Subtypes of alpha 2-adrenoceptors: pharmacological and molecular biological evidence converge. Trends Pharmacol. Sci., 9, 356361.
  • Bylund, D.B., Eikenberg, D.C., Hieble, J.P., Langer, S.Z., Lefkowitz, R.J., Minneman, K.P., Molinoff, P.B., Ruffolo, R.R. Jr & Trendelenburg, U. (1994) International Union of Pharmacology nomenclature of adrenoceptors. Pharmacol. Rev., 46, 121136.
  • Eisenach, J.C., Shafer, S.L., Bucklin, B.A., Jackson, C. & Kallio, A. (1994) Pharmacokinetics and pharmacodynamics of intraspinal dexmedetomidine in sheep. Anesthesiology, 80, 13491359.
  • Eisenach, J.C., DuPen, S., Dubois, M., Miguel, R. & Allin, D. (1995) Epidural clonidine analgesia for intractable cancer pain. The Epidural Clonidine Study Group. Pain, 61, 391399.
  • Faber, E.S., Chambers, J.P. & Evans, R.H. (1998) Depression of NMDA receptor-mediated synaptic transmission by four alpha2 adrenoceptor agonists on the in vitro rat spinal cord preparation. Br. J. Pharmacol., 124, 507512.
  • Fairbanks, C.A., Stone, L.S., Kitto, K.F., Nguyen, H.O., Posthumus, I.J. & Wilcox, G.L. (2002) alpha(2C)-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy. J. Pharmacol. Exp. Ther., 300, 282290.
  • Filos, K.S., Goudas, L.C., Patroni, O. & Polyzou, V. (1994) Hemodynamic and analgesic profile after intrathecal clonidine in humans. A dose-response study. Anesthesiology, 81, 591601.
  • Fisher, B., Zornow, M.H., Yaksh, T.L. & Peterson, B.M. (1991) Antinociceptive properties of intrathecal dexmedetomidine in rats. Eur. J. Pharmacol., 192, 221225.
  • Ghignone, M., Quintin, L., Duke, P.C., Kehler, C.H. & Calvillo, O. (1986) Effects of clonidine on narcotic requirements and hemodynamic response during induction of fentanyl anesthesia and endotracheal intubation. Anesthesiology, 64, 3642.
  • Ghignone, M., Calvillo, O. & Quintin, L. (1987) Anesthesia and hypertension: the effect of clonidine on perioperative hemodynamics and isoflurane requirements. Anesthesiology, 67, 310.
  • Guo, T.Z., Jiang, J.Y., Buttermann, A.E. & Maze, M. (1996) Dexmedetomidine injection into the locus ceruleus produces antinociception. Anesthesiology, 84, 873881.
  • Jasper, J.R., Lesnick, J.D., Chang, L.K., Yamanishi, S.S., Chang, T.K., Hsu, S.A., Daunt, D.A., Bonhaus, D.W. & Eglen, R.M. (1998) Ligand efficacy and potency at recombinant alpha2 adrenergic receptors: agonist-mediated [35S]GTPgammaS binding. Biochem. Pharmacol., 55, 10351043.
  • Kawasaki, Y., Kumamoto, E., Furue, H. & Yoshimura, M. (2003) Alpha 2 adrenoceptor-mediated presynaptic inhibition of primary afferent glutamatergic transmission in rat substantia gelatinosa neurons. Anesthesiology, 98, 682689.
  • Koga, A., Fujita, T., Totoki, T. & Kumamoto, E. (2005) Tramadol produces outward currents by activating mu-opioid receptors in adult rat substantia gelatinosa neurones. Br. J. Pharmacol., 145, 602607.
  • Kohno, T., Moore, K.A., Baba, H. & Woolf, C.J. (2003) Peripheral nerve injury alters excitatory synaptic transmission in lamina II of the rat dorsal horn. J. Physiol., 548, 131138.
  • Kumazawa, T. & Perl, E.R. (1978) Excitation of marginal and substantia gelatinosa neurons in the primate spinal cord: indications of their place in dorsal horn functional organization. J. Comp. Neurol., 177, 417434.
  • Li, P. & Zhuo, M. (2001) Cholinergic, noradrenergic, and serotonergic inhibition of fast synaptic transmission in spinal lumbar dorsal horn of rat. Brain Res. Bull., 54, 639647.
  • MacDonald, E., Kobilka, B.K. & Scheinin, M. (1997) Gene targeting – homing in on alpha 2-adrenoceptor-subtype function. Trends Pharmacol. Sci., 18, 211219.
  • Marjamaki, A., Luomala, K., Ala-Uotila, S. & Scheinin, M. (1993) Use of recombinant human alpha 2-adrenoceptors to characterize subtype selectively of antagonist binding. Eur. J. Pharmacol., 246, 219226.
  • Marker, C.L., Lujan, R., Loh, H.H. & Wickman, K. (2005) Spinal G-protein-gated potassium channels contribute in a dose-dependent manner to the analgesic effect of mu- and delta- but not kappa-opioids. J. Neurosci., 25, 35513559.
  • Maze, M., Birch, B. & Vickery, R.G. (1987) Clonidine reduces halothane MAC in rats. Anesthesiology, 67, 868869.
  • Mitrovic, I., Margeta-Mitrovic, M., Bader, S., Stoffel, M., Jan, L.Y. & Basbaum, A.I. (2003) Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences. Proc. Natl Acad. Sci. U.S.A., 100, 271276.
  • Miyazaki, T., Kobayashi, H. & Tosaka, T. (1998) Presynaptic inhibition by noradrenaline of the EPSC evoked in neonatal rat sympathetic preganglionic neurons. Brain Res., 790, 170177.
  • Nicholas, A.P., Pieribone, V. & Hokfelt, T. (1993) Distributions of mRNAs for alpha-2 adrenergic receptor subtypes in rat brain: an in situ hybridization study. J. Comp. Neurol., 328, 575594.
  • Olave, M.J. & Maxwell, D.J. (2002) An investigation of neurones that possess the alpha 2C-adrenergic receptor in the rat dorsal horn. Neuroscience, 115, 3140.
  • Pan, Y.Z., Li, D.P. & Pan, H.L. (2002) Inhibition of glutamatergic synaptic input to spinal lamina II(o) neurons by presynaptic alpha(2)-adrenergic receptors. J. Neurophysiol., 87, 19381947.
  • Roudet, C., Mouchet, P., Feuerstein, C. & Savasta, M. (1994) Normal distribution of alpha 2-adrenoceptors in the rat spinal cord and its modification after noradrenergic denervation: a quantitative autoradiographic study. J. Neurosci. Res., 39, 319329.
  • Ruscheweyh, R. & Sandkuhler, J. (2000) Differential actions of spinal analgesics on mono-versus polysynaptic Adelta-fibre-evoked field potentials in superficial spinal dorsal horn in vitro. Pain, 88, 97108.
  • Sallinen, J., Hoglund, I., Engstrom, M., Lehtimaki, J., Virtanen, R., Sirvio, J., Wurster, S., Savola, J.M. & Haapalinna, A. (2007) Pharmacological characterization and CNS effects of a novel highly selective alpha2C-adrenoceptor antagonist JP-1302. Br. J. Pharmacol., 150, 391402.
  • Savola, J.M. & Virtanen, R. (1991) Central alpha 2-adrenoceptors are highly stereoselective for dexmedetomidine, the dextro enantiomer of medetomidine. Eur. J. Pharmacol., 195, 193199.
  • Savola, J.M., Ruskoaho, H., Puurunen, J., Salonen, J.S. & Karki, N.T. (1986) Evidence for medetomidine as a selective and potent agonist at alpha 2-adrenoreceptors. J. Auton. Pharmacol., 6, 275284.
  • Segal, I.S., Vickery, R.G., Walton, J.K., Doze, V.A. & Maze, M. (1988) Dexmedetomidine diminishes halothane anesthetic requirements in rats through a postsynaptic alpha 2 adrenergic receptor. Anesthesiology, 69, 818823.
  • Shi, T.J., Winzer-Serhan, U., Leslie, F. & Hokfelt, T. (1999) Distribution of alpha2-adrenoceptor mRNAs in the rat lumbar spinal cord in normal and axotomized rats. Neuroreport, 10, 28352839.
  • Sonohata, M., Furue, H., Katafuchi, T., Yasaka, T., Doi, A., Kumamoto, E. & Yoshimura, M. (2004) Actions of noradrenaline on substantia gelatinosa neurones in the rat spinal cord revealed by in vivo patch recording. J. Physiol., 555, 515526.
  • Stone, L.S., Broberger, C., Vulchanova, L., Wilcox, G.L., Hokfelt, T., Riedl, M.S. & Elde, R. (1998) Differential distribution of alpha2A and alpha2C adrenergic receptor immunoreactivity in the rat spinal cord. J. Neurosci., 18, 59285937.
  • Takano, Y. & Yaksh, T.L. (1991) Relative efficacy of spinal alpha-2 agonists, dexmedetomidine, clonidine and ST-91, determined in vivo by using N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, an irreversible antagonist. J. Pharmacol. Exp. Ther., 258, 438446.
  • Venn, R.M. & Grounds, R.M. (2001) Comparison between dexmedetomidine and propofol for sedation in the intensive care unit: patient and clinician perceptions. Br. J. Anaesth., 87, 684690.
  • Virtanen, R., Savola, J.M., Saano, V. & Nyman, L. (1988) Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur. J. Pharmacol., 150, 914.
  • Wang, M.Y., Rampil, I.J. & Kendig, J.J. (1999) Ethanol directly depresses AMPA and NMDA glutamate currents in spinal cord motor neurons independent of actions on GABAA or glycine receptors. J. Pharmacol. Exp. Ther., 290, 362367.
  • Yajiri, Y., Yoshimura, M., Okamoto, M., Takahashi, H. & Higashi, H. (1997) A novel slow excitatory postsynaptic current in substantia gelatinosa neurons of the rat spinal cord in vitro. Neuroscience, 76, 673688.
  • Yaksh, T.L. (1985) Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing. Pharmacol. Biochem. Behav., 22, 845858.
  • Yoshimura, M. & Jessell, T.M. (1989) Primary afferent-evoked synaptic responses and slow potential generation in rat substantia gelatinosa neurons in vitro. J. Neurophysiol., 62, 96108.
  • Yoshimura, M. & Nishi, S. (1993) Blind patch-clamp recordings from substantia gelatinosa neurons in adult rat spinal cord slices: pharmacological properties of synaptic currents. Neuroscience, 53, 519526.