Disclosure: The authors have reported no conflicts of interest.
Characterisation of tremor-associated local field potentials in the subthalamic nucleus in Parkinson’s disease
Article first published online: 29 JAN 2009
© The Authors (2009). Journal Compilation © Federation of European Neuroscience Societies and Blackwell Publishing Ltd
European Journal of Neuroscience
Volume 29, Issue 3, pages 599–612, February 2009
How to Cite
Reck, C., Florin, E., Wojtecki, L., Krause, H., Groiss, S., Voges, J., Maarouf, M., Sturm, V., Schnitzler, A. and Timmermann, L. (2009), Characterisation of tremor-associated local field potentials in the subthalamic nucleus in Parkinson’s disease. European Journal of Neuroscience, 29: 599–612. doi: 10.1111/j.1460-9568.2008.06597.x
- Issue published online: 2 FEB 2009
- Article first published online: 29 JAN 2009
- Received 5 July 2008, revised 12 November 2008, accepted 25 November 2008
- deep brain stimulation;
We simultaneously recorded local field potentials (LFPs) in the subthalamic nucleus (STN) and surface electromyographic signals (EMGs) from the extensor and flexor muscles of the contralateral forearm in eight patients with idiopathic tremor-dominant Parkinson’s disease (resting tremor) during the bilateral implantation of deep brain stimulation electrodes. Recordings were made at different heights (in 0.5- to 2.0-mm steps beginning outside the STN) using up to five concentrically configured macroelectrodes (2 mm apart). The patients were instructed to relax their contralateral forearm (rest condition). We analysed the coherence between tremor EMGs and STN LFPs, which showed significant tremor-associated coupling at single tremor and double tremor frequencies. Moreover, the EMG–LFP coherences were characterised by differences between antagonistic muscles (flexor, extensor) and by the spatial distribution of LFPs within the STN. Coherence at single and double tremor frequencies occurred significantly more frequently within STN than above STN (in the zona incerta). In this study, we were able to show that, within STN, tremor-associated LFP activity varied with spatial distribution and with the contralateral antagonistic forearm muscles. These findings suggest the existence of distribution- and muscle-specific tremor-associated LFP activity at different tremor frequencies and an organisation of tremor-related subloops within the STN.