G.W., Y.T.Q. and T.L. contributed equally to this work.
Anopheles gambiae TRPA1 is a heat-activated channel expressed in thermosensitive sensilla of female antennae
Article first published online: 4 SEP 2009
© The Authors (2009). Journal Compilation © Federation of European Neuroscience Societies and Blackwell Publishing Ltd
European Journal of Neuroscience
Volume 30, Issue 6, pages 967–974, September 2009
How to Cite
Wang, G., Qiu, Y. T., Lu, T., Kwon, H.-W., Jason Pitts, R., Van Loon, J. J. A., Takken, W. and Zwiebel, L. J. (2009), Anopheles gambiae TRPA1 is a heat-activated channel expressed in thermosensitive sensilla of female antennae. European Journal of Neuroscience, 30: 967–974. doi: 10.1111/j.1460-9568.2009.06901.x
- Issue published online: 14 SEP 2009
- Article first published online: 4 SEP 2009
- Received 1 May 2009, revised 22 June 2009, accepted 15 July 2009
- coeloconic sensilla;
- temperature receptor;
- TRP channel
Heat sensitivity is a sensory modality that plays a critical role in close-range host-seeking behaviors of adult female Anopheles gambiae, the principal Afrotropical vector for human malaria. An essential step in this activity is the ability to discriminate and respond to increases in environmental temperature gradients through the process of peripheral thermoreception. Here, we report on the characterization of the anopheline homolog of the transient receptor potential (TRP) A1/ANKTM1 channel that is consistent with its role as a heat-sensor in host-seeking adult female mosquitoes. We identify a set of distal antennal sensory structures that specifically respond to temperature gradients and express AgTRPA1. Functional characterization of AgTRPA1 in Xenopus oocytes supports its role in the molecular transduction of temperature gradients in An. gambiae, providing a basis for targeting mosquito heat responses as a means toward reducing malaria transmission.