Fig. S1. Co-occurrence of BACE1 or Aβ with TH and NADPH-d around swollen/dystrophic axon terminals in the striatum and cortex.

Fig. S2. Initial occurrence of 3D6, 6E10 and BACE1 labeling in 5XFAD mouse brain before plaque onset.

Fig. S3. Age-related pattern of changes in 3D6 and β-secretase-1 labeling around cortical pyramidal neurons and compact plaques in 5XFAD mice.

Fig. S4. Additional trials of correlated measurements of BACE1/3D6 immunoreactivity relative to plaque size.

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