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Fig. S1. Strategy and confirmation of motopsin gene targeting.

Fig. S2. Normal motor coordination of motopsin knockout mice.

Fig. S3. Analysis of swimming distance in a probe test of Morris water maze.

Fig. S4. Similar foot-shock sensitivity, memory retention, and level of CREB

phosphorylation in a passive avoidance test.

Fig. S5. CREB phosphorylation after social isolation and water stresses.

Fig. S6. Hormonal response and CREB phosphorylation after restraint stress.

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