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Fig. S1. Effect of the i.p. administration of XE991 (3mg/kg) on the firing rate of DA neurons in the absence of a GABA antagonist.

Fig. S2. Comparison of the interspike intervals.

Fig. S3. Relative frequency of bursts as a function of their number of spikes, and changes in spike amplitude within bursts.

Fig. S4. Comparing i.p and iontophoretic application of vehicle

Fig. S5. Effect of M-channel blockade on the distribution of short interspike intervals.

Fig. S6. Effect of M-current blockade on a DA neuron model when the M current conductance was identical to the one reported experimentally.

Table S1: SR95531 blocks the inhibitory effect of GABA on the firing of DA neurons.

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