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Generation of interneuron diversity in the mouse cerebral cortex
Article first published online: 7 JUN 2010
DOI: 10.1111/j.1460-9568.2010.07267.x
© The Authors (2010). Journal Compilation © Federation of European Neuroscience Societies and Blackwell Publishing Ltd
Issue
European Journal of Neuroscience
Special Issue: On the occasion of the 7th FENS Forum, Amsterdam 2010
Volume 31, Issue 12, pages 2136–2141, June 2010
Additional Information
How to Cite
Gelman, D. M. and Marín, O. (2010), Generation of interneuron diversity in the mouse cerebral cortex. European Journal of Neuroscience, 31: 2136–2141. doi: 10.1111/j.1460-9568.2010.07267.x
Publication History
- Issue published online: 21 JUN 2010
- Article first published online: 7 JUN 2010
- Received 19 March 2010, accepted 9 April 2010
- Abstract
- Article
- References
- Cited By
Keywords:
- cell diversity;
- cortical development;
- GABA;
- interneuron;
- migration
Abstract
Gamma-aminobutyric acid-containing (GABAergic) interneurons play an important role in the function of the cerebral cortex. Through mostly inhibitory mechanisms, interneurons control hyperexcitability, and synchronize and shape the spatiotemporal dynamics of cortical activity underlying various brain functions. Their influence on cortical function is remarkably diverse, a reflection of the large variety of interneuronal populations that exist in the mammalian cortex. Research over the past few years has rapidly transformed our understanding of their mechanisms underlying the generation of different classes of interneurons. In this review, we summarize recent progress on this process, progress which holds the promise of providing a rational framework for their classification, as well as means to understand their role in cortical processing.