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Activity-dependent dendritic secretion of brain-derived neurotrophic factor modulates synaptic plasticity

Authors

  • Nicola Kuczewski,

    1. INMED (Institut de Neurobiologie de la Méditerranée), INSERM (Institut National de la Santé et de la Recherche Médicale Unité 901) and Université de La Méditerranée, Parc scientifique de Luminy, BP 13, 13273 Marseille Cedex 09, France
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  • Christophe Porcher,

    1. INMED (Institut de Neurobiologie de la Méditerranée), INSERM (Institut National de la Santé et de la Recherche Médicale Unité 901) and Université de La Méditerranée, Parc scientifique de Luminy, BP 13, 13273 Marseille Cedex 09, France
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  • Jean-Luc Gaiarsa

    1. INMED (Institut de Neurobiologie de la Méditerranée), INSERM (Institut National de la Santé et de la Recherche Médicale Unité 901) and Université de La Méditerranée, Parc scientifique de Luminy, BP 13, 13273 Marseille Cedex 09, France
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Jean-Luc Gaiarsa, as above.
E-mail: gaiarsa@inmed.univ-mrs.fr

Abstract

During the last decade, a major role has emerged for brain-derived neurotrophic factor (BDNF) in the translation of intrinsic or sensory-driven synaptic activities into the neuronal network plasticity that sculpts neural circuits. BDNF is released from dendrites and axons in response to synaptic activity and modulates many aspects of synaptic function. Although the importance of BDNF in synaptic plasticity has been clearly established, direct evidence for a specific contribution of the activity-dependent dendritic secretion of BDNF has been difficult to obtain. This review summarizes recent advances that have established specific effects of postsynaptic BDNF secretion on synapse efficacy and development. We will also discuss these data in the light of their functional and pathological significance.

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