Present address: Department of Neurology, Higashi Nagoya Hospital, 101 Umemorizaka 5-chome, Meito-ku, Nagoya, Aichi 466-0065, Japan.
Calcium dependence of the priming, activation and inactivation of ryanodine receptors in frog motor nerve terminals
Version of Record online: 26 AUG 2010
© 2010 The Authors. European Journal of Neuroscience © 2010 Federation of European Neuroscience Societies and Blackwell Publishing Ltd
European Journal of Neuroscience
Volume 32, Issue 6, pages 948–962, September 2010
How to Cite
Soga-Sakakibara, S., Kubota, M., Suzuki, S., Akita, T., Narita, K. and Kuba, K. (2010), Calcium dependence of the priming, activation and inactivation of ryanodine receptors in frog motor nerve terminals. European Journal of Neuroscience, 32: 948–962. doi: 10.1111/j.1460-9568.2010.07381.x
- Issue online: 17 SEP 2010
- Version of Record online: 26 AUG 2010
- Received 1 May 2010, revised 12 June 2010, accepted 21 June 2010
Fig. S1. Effects of CPA on short tetanus-induced rises in [Ca2+]i.
Fig. S2. Reversible effects of TMB-8 on repetitive tetani-induced Ca2+ transients.
Fig. S3. The relationship between the active fraction of ‘Ca2+ domain unit’ and the fraction of the unblocked Ca2+ channels under the effects of wCGTX.
Fig. S4. Simulation of the time courses of [Ca2+]i(b), [Ca2+]i(d), Rp, when CICR is activated or not, and the dependence of Rp on [Ca2+]o and Ca2+ channel density in the three-compartment model.
Fig. S5. Simulation of the dependence of CICR on [Ca2+]o and Ca2+ channel density and effects of exogenous Ca2+ buffers.
Table S1.Parameter values for simulation.
Data S1. Differential equations, their bases and the simulation procedures.
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