Changes in molecular composition of rat medial prefrontal cortex synapses during adolescent development
Version of Record online: 18 OCT 2010
© 2010 The Authors. European Journal of Neuroscience © 2010 Federation of European Neuroscience Societies and Blackwell Publishing Ltd
European Journal of Neuroscience
Volume 32, Issue 9, pages 1452–1460, November 2010
How to Cite
Counotte, D. S., Li, K. W., Wortel, J., Gouwenberg, Y., Van Der Schors, R. C., Smit, A. B. and Spijker, S. (2010), Changes in molecular composition of rat medial prefrontal cortex synapses during adolescent development. European Journal of Neuroscience, 32: 1452–1460. doi: 10.1111/j.1460-9568.2010.07404.x
- Issue online: 2 NOV 2010
- Version of Record online: 18 OCT 2010
- Received 10 March 2010, accepted 14 July 2010
Fig. S1. Overview of regulated proteins during development.
Fig. S2. Hierarchical clustering of the significantly regulated proteins revealed 2 small (cluster 1 and 5) and three major clusters (clusters 2–5), indicated by blue shading on the branches of the tree.
Fig. S3. Immunoblotting on mPFC and MCtx homogenate of different developmental time points revealed no differences in neuron number (NeuN) and the number of pre- and postsynaptic proteins (Psd-95 and Piccolo).
Fig. S4. Immunoblotting on mPFC synaptosomes at different time points for synaptic vesicle proteins that are attached to the membrane (A; red) or integral to the membrane (B; blue).
Table S1. Proteomics overview.
Table S2. Postnatal developmental regulation of mPFC synaptic proteins.
Table S3. Grouping of mPFC synaptic proteins.
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