Deep brain stimulation in clinical trials and animal models of depression

Authors

  • Clement Hamani,

    1. Neuroimaging Research Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada
    2. Division of Neurosurgery, Toronto Western Hospital, Toronto, ON, Canada
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  • José N. Nóbrega

    1. Neuroimaging Research Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada
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Dr C. Hamani, 1Neuroimaging Research Section, as above.
E-mail: Clement.Hamani@uhn.on.ca

Abstract

Deep brain stimulation (DBS) is currently being investigated as a therapy for the treatment of depression. Despite promising results of recent clinical trials, neural and chemical mechanisms responsible for the effects of stimulation are still unclear. In this article, we review clinical and laboratory findings on DBS for depression. Particular emphasis will be given to aspects involved in the translation of data from animal models to humans and in our findings on the potential substrates involved in the antidepressant effects of DBS in rats.

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