Integration and maturation of newborn neurons in the adult olfactory bulb – from synapses to function

Authors

  • Antoine Nissant,

    1. Institut Pasteur, Laboratory for Perception and Memory, F-75015 Paris, France.
    2. Centre National de la Recherche Scientifique (CNRS) Unité de Recherche Associée (URA) 2182, F-75015 Paris, France.
    Search for more papers by this author
  • Marta Pallotto

    1. Institut Pasteur, Laboratory for Perception and Memory, F-75015 Paris, France.
    2. Centre National de la Recherche Scientifique (CNRS) Unité de Recherche Associée (URA) 2182, F-75015 Paris, France.
    3. Department of Anatomy, Pharmacology and Forensic Medicine, and National Institute of Neuroscience-Italy, University of Turin, Turin, Italy
    Search for more papers by this author

Dr A. Nissant, as above.
E-mail: anissant@pasteur.fr.

Abstract

In adult mammals, thousands of new neurons integrate in the olfactory bulb (OB) each day. This process of adult neurogenesis has received a great deal of scientific attention aimed at understanding how mature neural networks withstand neuronal replacement, and medical interest to explore the promise that these cells may be manipulated for brain repair therapies. In the present review, we focus on the mechanisms and consequences of the functional integration of newborn interneurons in the OB network. We first describe the steps of synaptic integration and functional maturation of adult-born interneurons in the OB. We then examine the physiological control of cell maturation and survival. Finally, we explore the potential impact of adult neurogenesis on the function of the OB.

Ancillary