C.B. and M.F. contributed equally to this work.
Glutamate released spontaneously from astrocytes sets the threshold for synaptic plasticity
Version of Record online: 14 MAR 2011
© 2011 The Authors. European Journal of Neuroscience © 2011 Federation of European Neuroscience Societies and Blackwell Publishing Ltd
European Journal of Neuroscience
Volume 33, Issue 8, pages 1483–1492, April 2011
How to Cite
Bonansco, C., Couve, A., Perea, G., Ferradas, C. Á., Roncagliolo, M. and Fuenzalida, M. (2011), Glutamate released spontaneously from astrocytes sets the threshold for synaptic plasticity. European Journal of Neuroscience, 33: 1483–1492. doi: 10.1111/j.1460-9568.2011.07631.x
- Issue online: 17 APR 2011
- Version of Record online: 14 MAR 2011
- Received 20 August 2010, revised 3 January 2011, accepted 19 January 2011
Fig. S1. The astrocytic metabolic arrests do not affect neuronal excitability. (A) Electrical responses of CA1 pyramidal neurons at depolarizing and hyperpolarizing current pulses of 250 ms duration applied in 10 pA steps before (left) and after (right) FC perfusion. (B) Action potentials generated by current ramp injections before (left) and during (right) application of FC. Membrane potential, −70 mV.
Fig. S2. The blockage of mGluRs increases the PPF. (A) Superimposed scaled average of EPSCs (10 sweeps) evoked by PPF protocol, in high extracellular Ca2+ conditions (thin line) and after the addition of MPEP plus LY367385 (LY367) (thick line). (B) Summary data of average PPF index recorded in control, in the presence of FC alone and MPEP plus LY367385, measured in ACSF (Normal Ca2+) and in high extracellular Ca2+ conditions (High Ca2+), before (baseline) and after the addition of MPEP plus LY367385, as shown in A. The numbers in the bars represent sample size (n). BAPTA-AM, 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetra-acetate.
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