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Fig. S1. The astrocytic metabolic arrests do not affect neuronal excitability. (A) Electrical responses of CA1 pyramidal neurons at depolarizing and hyperpolarizing current pulses of 250 ms duration applied in 10 pA steps before (left) and after (right) FC perfusion. (B) Action potentials generated by current ramp injections before (left) and during (right) application of FC. Membrane potential, −70 mV.

Fig. S2. The blockage of mGluRs increases the PPF. (A) Superimposed scaled average of EPSCs (10 sweeps) evoked by PPF protocol, in high extracellular Ca2+ conditions (thin line) and after the addition of MPEP plus LY367385 (LY367) (thick line). (B) Summary data of average PPF index recorded in control, in the presence of FC alone and MPEP plus LY367385, measured in ACSF (Normal Ca2+) and in high extracellular Ca2+ conditions (High Ca2+), before (baseline) and after the addition of MPEP plus LY367385, as shown in A. The numbers in the bars represent sample size (n). BAPTA-AM, 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetra-acetate.

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