C.B. and M.F. contributed equally to this work.
Glutamate released spontaneously from astrocytes sets the threshold for synaptic plasticity
Article first published online: 14 MAR 2011
© 2011 The Authors. European Journal of Neuroscience © 2011 Federation of European Neuroscience Societies and Blackwell Publishing Ltd
European Journal of Neuroscience
Volume 33, Issue 8, pages 1483–1492, April 2011
How to Cite
Bonansco, C., Couve, A., Perea, G., Ferradas, C. Á., Roncagliolo, M. and Fuenzalida, M. (2011), Glutamate released spontaneously from astrocytes sets the threshold for synaptic plasticity. European Journal of Neuroscience, 33: 1483–1492. doi: 10.1111/j.1460-9568.2011.07631.x
- Issue published online: 17 APR 2011
- Article first published online: 14 MAR 2011
- Received 20 August 2010, revised 3 January 2011, accepted 19 January 2011
Fig. S1. The astrocytic metabolic arrests do not affect neuronal excitability. (A) Electrical responses of CA1 pyramidal neurons at depolarizing and hyperpolarizing current pulses of 250 ms duration applied in 10 pA steps before (left) and after (right) FC perfusion. (B) Action potentials generated by current ramp injections before (left) and during (right) application of FC. Membrane potential, −70 mV.
Fig. S2. The blockage of mGluRs increases the PPF. (A) Superimposed scaled average of EPSCs (10 sweeps) evoked by PPF protocol, in high extracellular Ca2+ conditions (thin line) and after the addition of MPEP plus LY367385 (LY367) (thick line). (B) Summary data of average PPF index recorded in control, in the presence of FC alone and MPEP plus LY367385, measured in ACSF (Normal Ca2+) and in high extracellular Ca2+ conditions (High Ca2+), before (baseline) and after the addition of MPEP plus LY367385, as shown in A. The numbers in the bars represent sample size (n). BAPTA-AM, 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetra-acetate.
As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer-reviewed and may be re-organized for online delivery, but are not copy-edited or typeset by Wiley-Blackwell. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
|EJN_7631_sm_figs1.tif||1149K||Supporting info item|
|EJN_7631_sm_figs2.tif||923K||Supporting info item|
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.