In vivo magnetic resonance imaging characterization of bilateral structural changes in experimental Parkinson’s disease: a T2 relaxometry study combined with longitudinal diffusion tensor imaging and manganese-enhanced magnetic resonance imaging in the 6-hydroxydopamine rat model
Article first published online: 17 MAR 2011
© 2011 The Authors. European Journal of Neuroscience © 2011 Federation of European Neuroscience Societies and Blackwell Publishing Ltd
European Journal of Neuroscience
Volume 33, Issue 8, pages 1551–1560, April 2011
How to Cite
Soria, G., Aguilar, E., Tudela, R., Mullol, J., Planas, A. M. and Marin, C. (2011), In vivo magnetic resonance imaging characterization of bilateral structural changes in experimental Parkinson’s disease: a T2 relaxometry study combined with longitudinal diffusion tensor imaging and manganese-enhanced magnetic resonance imaging in the 6-hydroxydopamine rat model. European Journal of Neuroscience, 33: 1551–1560. doi: 10.1111/j.1460-9568.2011.07639.x
- Issue published online: 17 APR 2011
- Article first published online: 17 MAR 2011
- Received 25 October 2010, revised 24 January 2011, accepted 27 January2011
Fig. S1. Representative coronal sections of sham and 6-OHDA-lesioned animals 24 h after manganese injection. 3D-T1 weighted images acquired with MDEFT sequence. See Materials and methods for details.
Fig. S2. Immunohistochemical evaluation of STN integrity after MnC12 injection. Representative NeuN immunohistochemistry in the STN from 14-mm coronal section of MnC12-injected and non-injected hemisphere. The subthalamic nucleus (STN) is pointed with an arrow. Images were obtained with an optical microscope using ×40 magnification.
Table S1 Averages oFFractional Anisotropy, Apparent Diffusion Coefficient, Axial and Radial Diffusivities calculated for different ROIs in the ipsilateral and contralateral hemispheres oFsham-operated and 6-OHDA-operated animals at the pre-lesion scan and 3 and 14 days after the injection. Data is expressed as mean ± standard deviation. *indicates significant differences vs. sham, dollar symbol indicates significant differences vs. pre-lesion measuremnts, T indicates differences vs hemispheres P < 0.05.
Table S2 Multiple ANOVAs for diffusion tensor imaging coefficient changes induced by 6-OHDA lesion.
Table S3 Pre-lesion T1 longitudinal relaxation times (ms) of sham- and 6-OHDA-operated animals. Data is expressed as mean ± standard deviation.
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