Modulation of astroglial glutamine synthetase activity affects nociceptive behaviour and central sensitization of medullary dorsal horn nociceptive neurons in a rat model of chronic pulpitis
Article first published online: 27 JUN 2011
© 2011 The Authors. European Journal of Neuroscience © 2011 Federation of European Neuroscience Societies and Blackwell Publishing Ltd
European Journal of Neuroscience
Volume 34, Issue 2, pages 292–302, July 2011
How to Cite
Tsuboi, Y., Iwata, K., Dostrovsky, J. O., Chiang, C. Y., Sessle, B. J. and Hu, J. W. (2011), Modulation of astroglial glutamine synthetase activity affects nociceptive behaviour and central sensitization of medullary dorsal horn nociceptive neurons in a rat model of chronic pulpitis. European Journal of Neuroscience, 34: 292–302. doi: 10.1111/j.1460-9568.2011.07747.x
- Issue published online: 18 JUL 2011
- Article first published online: 27 JUN 2011
- Received 25 February 2011, revised 8 April 2011, accepted 28 April 2011
Fig. S1. The time course change in body weight following tooth pulp exposure. No differences were found between intact (control) and pulp-exposed rats (P& >& 0.05; two-way RM anova). Pre, before pulp-exposure surgery.
Fig. S2. Effect of MSO on evoked responses of MDH nociceptive neurons in the rats with intact tooth pulp. Intrathecal MSO (10& mm) application produced no changes in neuronal activities for different intensities of mechanical stimulation of WDR neurons. One-way anova revealed no changes over time (P& >& 0.05).
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