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Fig. S1. The time course change in body weight following tooth pulp exposure. No differences were found between intact (control) and pulp-exposed rats (P& >&  0.05; two-way RM anova). Pre, before pulp-exposure surgery.

Fig. S2. Effect of MSO on evoked responses of MDH nociceptive neurons in the rats with intact tooth pulp. Intrathecal MSO (10& mm) application produced no changes in neuronal activities for different intensities of mechanical stimulation of WDR neurons. One-way anova revealed no changes over time (P& >&  0.05).

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