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Fig. S1. (A) The specific CRFR1 antagonist CP154526 (100 nm) blocked UCN-induced CREB phosphorylation (F3,110 = 18.60, < 0.001). (B) The CRFR2-specific inhibitory peptide antisauvagine-30 (100 nm) had no effect on UCN-induced CREB phosphorylation (F3,123 = 40.27, > 0.05). (C) The AC antagonist SQ22536 (90 μm) failed to affect UCN-induced CREB phosphorylation (F3,113 = 25.34, > 0.05). (D) A PKA-specific concentration of the protein kinase inhibitor H89 (2 μm) did not block UCN-induced CREB phosphorylation (F3,118 = 27.19, > 0.05).

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