Corticotropin-releasing factor and urocortin I activate CREB through functionally selective Gβγ signaling in hippocampal pyramidal neurons
Article first published online: 8 AUG 2011
© 2011 The Authors. European Journal of Neuroscience © 2011 Federation of European Neuroscience Societies and Blackwell Publishing Ltd
European Journal of Neuroscience
Volume 34, Issue 5, pages 671–681, September 2011
How to Cite
Stern, C. M., Meitzen, J. and Mermelstein, P. G. (2011), Corticotropin-releasing factor and urocortin I activate CREB through functionally selective Gβγ signaling in hippocampal pyramidal neurons. European Journal of Neuroscience, 34: 671–681. doi: 10.1111/j.1460-9568.2011.07812.x
- Issue published online: 5 SEP 2011
- Article first published online: 8 AUG 2011
- Received 8 May 2011, revised 17 June 2011, accepted 24 June 2011
Fig. S1. (A) The specific CRFR1 antagonist CP154526 (100 nm) blocked UCN-induced CREB phosphorylation (F3,110 = 18.60, P < 0.001). (B) The CRFR2-specific inhibitory peptide antisauvagine-30 (100 nm) had no effect on UCN-induced CREB phosphorylation (F3,123 = 40.27, P > 0.05). (C) The AC antagonist SQ22536 (90 μm) failed to affect UCN-induced CREB phosphorylation (F3,113 = 25.34, P > 0.05). (D) A PKA-specific concentration of the protein kinase inhibitor H89 (2 μm) did not block UCN-induced CREB phosphorylation (F3,118 = 27.19, P > 0.05).
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