M.S. and C.K. contributed equally to this work.
Synchronized spike waves in immature dentate gyrus networks
Article first published online: 15 FEB 2012
© 2012 The Authors. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd
European Journal of Neuroscience
Volume 35, Issue 5, pages 673–681, March 2012
How to Cite
Seki, M., Kobayashi, C., Takahashi, N., Matsuki, N. and Ikegaya, Y. (2012), Synchronized spike waves in immature dentate gyrus networks. European Journal of Neuroscience, 35: 673–681. doi: 10.1111/j.1460-9568.2012.07995.x
- Issue published online: 6 MAR 2012
- Article first published online: 15 FEB 2012
- Received 12 September 2011, revised 14 November 2011, accepted 11 December 2011
- learning and memory;
At early developmental stages, immature neuronal networks of the neocortex and hippocampus spontaneously exhibit synchronously oscillating activities, which are believed to play roles in normal circuit maturation. The tissue development of the dentate gyrus (DG) in the hippocampal formation is exceptionally late compared with other brain regions and persists until postnatal periods. Using patch-clamp recording and functional multineuron calcium imaging, we found that the DG networks of postnatal day (P)3–7 mice spontaneously generated traveling waves of action potentials, which were initiated at the upper blade of the granule cell layer and propagated to the lower blade. The propagation was dependent on glutamatergic and electrical synapses, but not on GABAergic receptor activity. Remarkably, the DG waves were almost completely abolished in offspring born to female rats exposed to restraint stress during pregnancy. In the prenatally stressed offspring, DG granule cell dendrites developed normally until P3 and showed atrophy by P9. Thus, the DG waves may be required for the maturation of DG granule cells.