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Orexin / hypocretin 1 receptor antagonist reduces heroin self-administration and cue-induced heroin seeking
Article first published online: 22 FEB 2012
DOI: 10.1111/j.1460-9568.2012.08013.x
© 2012 The Authors. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd
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How to Cite
Smith, R. J. and Aston-Jones, G. (2012), Orexin / hypocretin 1 receptor antagonist reduces heroin self-administration and cue-induced heroin seeking. European Journal of Neuroscience, 35: 798–804. doi: 10.1111/j.1460-9568.2012.08013.x
Publication History
- Issue published online: 6 MAR 2012
- Article first published online: 22 FEB 2012
- Received 9 August 2011, revised 8 December 2011, accepted 20 December 2011
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Keywords:
- addiction;
- opiates;
- rats;
- reinstatement;
- relapse
Abstract
The orexin/hypocretin system is involved in several addiction-related behaviors. In the present experiments, we examined the involvement of orexin in heroin reinforcement and relapse by administering the orexin 1 receptor antagonist SB-334867 prior to heroin self-administration or prior to cue-induced or heroin-induced reinstatement of extinguished heroin seeking in male Sprague Dawley rats. SB-334867 (30 mg/kg, intraperitoneal) reduced heroin intake during self-administration under fixed ratio-1 and progressive ratio schedules. SB-334867 also attenuated reinstatement of heroin seeking elicited by cues, but not reinstatement elicited by a heroin prime. These results indicate that orexin antagonism reduces heroin self-administration, and they support a role for orexin in cue-triggered drug relapse.