These authors contributed equally to this work.
Perceived helplessness is associated with individual differences in the central motor output system
Article first published online: 7 MAY 2012
© 2012 The Authors. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd
European Journal of Neuroscience
Volume 35, Issue 9, pages 1481–1487, May 2012
How to Cite
Salomons, T. V., Moayedi, M., Weissman-Fogel, I., Goldberg, M. B., Freeman, B. V., Tenenbaum, H. C. and Davis, K. D. (2012), Perceived helplessness is associated with individual differences in the central motor output system. European Journal of Neuroscience, 35: 1481–1487. doi: 10.1111/j.1460-9568.2012.08048.x
- Issue published online: 7 MAY 2012
- Article first published online: 7 MAY 2012
- Received 16 January 2012, accepted 23 January 2012
- cortical thickness;
- fractional anisotropy;
- temporomandibular disorder;
Learned helplessness is a maladaptive response to uncontrollable stress characterized by impaired motor escape responses, reduced motivation and learning deficits. There are important individual differences in the likelihood of becoming helpless following exposure to uncontrollable stress but little is known about the neural mechanisms underlying these individual differences. Here we used structural MRI to measure gray and white matter in individuals with chronic pain, a population at high risk for helplessness due to prolonged exposure to a poorly controlled stressor (pain). Given that self-reported helplessness is predictive of treatment outcomes in chronic pain, understanding such differences might provide valuable clinical insight. We found that the magnitude of self-reported helplessness correlated with cortical thickness in the supplementary motor area (SMA) and midcingulate cortex, regions implicated in cognitive aspects of motor behavior. We then examined the white matter connectivity of these regions and found that fractional anisotropy of connected white matter tracts along the corticospinal tract was associated with helplessness and mediated the relationship between SMA cortical thickness and helplessness. These data provide novel evidence that links individual differences in the motor output pathway with perceived helplessness over a chronic and poorly controlled stressor.