Present addresses: Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, PA 19104, USA.
Novel biochemical manipulation of brain serotonin reveals a role of serotonin in the circadian rhythm of sleep–wake cycles
Article first published online: 24 MAY 2012
© 2012 The Authors. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd
European Journal of Neuroscience
Volume 35, Issue 11, pages 1762–1770, June 2012
How to Cite
Nakamaru-Ogiso, E., Miyamoto, H., Hamada, K., Tsukada, K. and Takai, K. (2012), Novel biochemical manipulation of brain serotonin reveals a role of serotonin in the circadian rhythm of sleep–wake cycles. European Journal of Neuroscience, 35: 1762–1770. doi: 10.1111/j.1460-9568.2012.08077.x
- Issue published online: 5 JUN 2012
- Article first published online: 24 MAY 2012
- Received 13 September 2011, revised 27 January 2012, accepted 13 February 2012
Fig. S1. Time courses of changes at the whole brain level of various amino acids after TSOI (20 units injection or saline injection as a control.
Fig. S2. Microdialysis studies of freely moving rats.
Fig. S3. Diurnal rhythms of regional brain temperatures were preserved after TSOI injection.
Table. S1. Effects of TSOI-induced 5-HT depletion on total sleep/waking time (min) in the light/dark phases (12 hrs).
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