Fig. S1. Time courses of changes at the whole brain level of various amino acids after TSOI (20 units injection or saline injection as a control.

Fig. S2. Microdialysis studies of freely moving rats.

Fig. S3. Diurnal rhythms of regional brain temperatures were preserved after TSOI injection.

Table. S1. Effects of TSOI-induced 5-HT depletion on total sleep/waking time (min) in the light/dark phases (12 hrs).

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