Cognitive dysfunction and depression in Parkinson’s disease: what can be learned from rodent models?
Article first published online: 19 JUN 2012
© 2012 The Authors. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd
European Journal of Neuroscience
Special Issue: EARLY BRAIN REPAIR AND PROTECTION
Volume 35, Issue 12, pages 1894–1907, June 2012
How to Cite
Lindgren, H. S. and Dunnett, S. B. (2012), Cognitive dysfunction and depression in Parkinson’s disease: what can be learned from rodent models?. European Journal of Neuroscience, 35: 1894–1907. doi: 10.1111/j.1460-9568.2012.08162.x
- Issue published online: 19 JUN 2012
- Article first published online: 19 JUN 2012
- Received 8 February 2012, revised 26 March 2012, accepted 12 April 2012
- Parkinson’s disease;
- rodent models;
Parkinson’s disease (PD) has for decades been considered a pure motor disorder and its cardinal motor symptoms have been attributed to the loss of dopaminergic (DAergic) neurons in the substantia nigra pars compacta and to nigral Lewy body pathology. However, there has more recently been a shift in the conceptualization of the disease, and its pathological features have now been recognized as involving several other areas of the brain and indeed even outside the central nervous system. There are a corresponding variety of intrinsic non-motor symptoms such as autonomic dysfunction, cognitive impairment, sleep disturbances and neuropsychiatric problems, which cannot be explained exclusively by nigral pathology. In this review, we will focus on cognitive impairment and affective symptoms in PD, and we will consider whether, and how, these deficits can best be modelled in rodent models of the disorder. As only a few of the non-motor symptoms respond to standard DA replacement therapies, the quest for a broader therapeutic approach remains a major research effort, and success in this area in particular will be strongly dependent on appropriate rodent models. In addition, better understanding of the different models, as well as the advantages and disadvantages of the available behavioural tasks, will result in better tools for evaluating new treatment strategies for PD patients suffering from these neuropsychological symptoms.