• Open Access

MicroRNA-132 regulates recognition memory and synaptic plasticity in the perirhinal cortex

Authors

  • Helen L. Scott,

    1. Henry Wellcome Laboratories for Integrative Neuroscience & Endocrinology & MRC Centre for Synaptic Plasticity, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol BS1 3NY, UK
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  • Francesco Tamagnini,

    1. School of Physiology and Pharmacology & MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, University Walk, Bristol, UK
    2. University of Bologna, Via Zamboni, Bologna, Italy
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  • Katherine E. Narduzzo,

    1. School of Physiology and Pharmacology & MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, University Walk, Bristol, UK
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  • Joanna L. Howarth,

    1. Henry Wellcome Laboratories for Integrative Neuroscience & Endocrinology & MRC Centre for Synaptic Plasticity, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol BS1 3NY, UK
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  • Youn-Bok Lee,

    1. Henry Wellcome Laboratories for Integrative Neuroscience & Endocrinology & MRC Centre for Synaptic Plasticity, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol BS1 3NY, UK
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  • Liang-Fong Wong,

    1. Henry Wellcome Laboratories for Integrative Neuroscience & Endocrinology & MRC Centre for Synaptic Plasticity, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol BS1 3NY, UK
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  • Malcolm W. Brown,

    1. School of Physiology and Pharmacology & MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, University Walk, Bristol, UK
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  • Elizabeth C. Warburton,

    1. School of Physiology and Pharmacology & MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, University Walk, Bristol, UK
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  • Zafar I. Bashir,

    1. University of Bologna, Via Zamboni, Bologna, Italy
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  • James B. Uney

    1. Henry Wellcome Laboratories for Integrative Neuroscience & Endocrinology & MRC Centre for Synaptic Plasticity, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol BS1 3NY, UK
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Dr Helen Scott and Professor James Uney, as above.
E-mails: helen.scott@bristol.ac.uk and james.uney@bristol.ac.uk

Abstract

Evidence suggests that the acquisition of recognition memory depends upon CREB-dependent long-lasting changes in synaptic plasticity in the perirhinal cortex.The CREB-responsive microRNA miR-132 has been shown to regulate synaptic transmission and we set out to investigate a role for this microRNA in recognition memory and its underlying plasticity mechanisms. To this end we mediated the specific overexpression of miR-132 selectively in the rat perirhinal cortex and demonstrated impairment in short-term recognition memory. This functional deficit was associated with a reduction in both long-term depression and long-term potentiation. These results confirm that microRNAs are key coordinators of the intracellular pathways that mediate experience-dependent changes in the brain. In addition, these results demonstrate a role for miR-132 in the neuronal mechanisms underlying the formation of short-term recognition memory.

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