E.S and A.B. contributed equally to this work.
Oscillatory entrainment of subthalamic nucleus neurons and behavioural consequences in rodents and primates
Article first published online: 31 JUL 2012
© 2012 The Authors. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd
European Journal of Neuroscience
Volume 36, Issue 9, pages 3246–3257, November 2012
How to Cite
Syed, E. C. J., Benazzouz, A., Taillade, M., Baufreton, J., Champeaux, K., Falgairolle, M., Bioulac, B., Gross, C. E. and Boraud, T. (2012), Oscillatory entrainment of subthalamic nucleus neurons and behavioural consequences in rodents and primates. European Journal of Neuroscience, 36: 3246–3257. doi: 10.1111/j.1460-9568.2012.08246.x
- Issue published online: 5 NOV 2012
- Article first published online: 31 JUL 2012
- Received 3 February 2012, revised 3 July 2012, accepted 5 July 2012
- beta oscillations;
- local field potentials;
- Parkinson’s disease;
We investigated the functional role of oscillatory activity in the local field potential (LFP) of the subthalamic nucleus (STN) in the pathophysiology of Parkinson’s disease (PD). It has been postulated that beta (15–30 Hz) oscillatory activity in the basal ganglia induces PD motor symptoms. To assess this hypothesis, an LFP showing significant power in the beta frequency range (23 Hz) was used as a stimulus both in vitro and in vivo. We first demonstrated in rat brain slices that STN neuronal activity was driven by the LFP stimulation. We then applied beta stimulation to the STN of 16 rats and two monkeys while quantifying motor behaviour. Although stimulation-induced behavioural effects were observed, stimulation of the STN at 23 Hz induced no significant decrease in motor performance in either rodents or primates. This study is the first to show LFP-induced behaviour in both rats and primates, and highlights the complex relationship between beta power and parkinsonian symptoms.