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Experimental epilepsy affects Notch1 signalling and the stem cell pool in the dentate gyrus

  1. Mirjam Sibbe1,*,
  2. Ute Häussler2,
  3. Sandra Dieni1,
  4. Daniel Althof1,3,4,
  5. Carola A. Haas2,
  6. Michael Frotscher1,5,*

Article first published online: 17 SEP 2012

DOI: 10.1111/j.1460-9568.2012.08279.x

Issue

European Journal of Neuroscience

European Journal of Neuroscience

Volume 36, Issue 12, pages 3643–3652, December 2012

Additional Information

How to Cite

Sibbe, M., Häussler, U., Dieni, S., Althof, D., Haas, C. A. and Frotscher, M. (2012), Experimental epilepsy affects Notch1 signalling and the stem cell pool in the dentate gyrus. European Journal of Neuroscience, 36: 3643–3652. doi: 10.1111/j.1460-9568.2012.08279.x

Author Information

  1. 1

    Institute of Anatomy and Cell Biology, University of Freiburg, Freiburg, Germany

  2. 2

    Experimental Epilepsy Research, Department of Neurosurgery, Faculty of Medicine, University of Freiburg, Freiburg, Germany

  3. 3

    Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany

  4. 4

    Faculty of Biology, University of Freiburg, Freiburg, Germany

  5. 5

    Institute for Structural Neurobiology, Center for Molecular Neurobiology Hamburg, Hamburg, Germany

* Correspondence: Mirjam Sibbe, 1Institute of Anatomy and Cell Biology, as above.
E-mail: Mirjam.Sibbe@anat.uni-freiburg.de
or
Michael Frotscher, 5Institute for Structural Neurobiology, as above.
E-mail: Michael.Frotscher@zmnh.uni-hamburg.de

Publication History

  1. Issue published online: 17 DEC 2012
  2. Article first published online: 17 SEP 2012
  3. Manuscript Accepted: 9 AUG 2012
  4. Manuscript Revised: 25 JUL 2012
  5. Manuscript Received: 7 NOV 2011

Funded by

  • Deutsche Forschungsgemeinschaft
  • Excellence Initiative of the German Federal and State Governments GSC-4
  • Spemann Graduate School
  • Hertie Foundation

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FilenameFormatSizeDescription
ejn8279-sup-0001-FigS1.tifimage/tif5651KFig. S1. Hes5-GFP/Nestin double-labeling. (A–I) Representative confocal images of the dentate molecular layer from (A–C) a control animal and from the (D–F) ipsilateral and (G–I) contralateral side of a KA-injected animal. Arrows point to Nestin+ cells. DAPI labelling is shown in blue. Scale bar: 25 µm. ML, molecular layer; GCL, granule cell layer.

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