Comparison of morphine and tramadol by patient-controlled analgesia for postoperative analgesia after tonsillectomy in children
Article first published online: 29 SEP 2005
Volume 15, Issue 11, pages 979–984, November 2005
How to Cite
ÖZALEVLI, M., ÜNLÜGENÇ, H., TUNCER, Ü., GÜNEŞ, Y. and ÖZCENGIZ, D. (2005), Comparison of morphine and tramadol by patient-controlled analgesia for postoperative analgesia after tonsillectomy in children. Pediatric Anesthesia, 15: 979–984. doi: 10.1111/j.1460-9592.2005.01591.x
- Issue published online: 17 OCT 2005
- Article first published online: 29 SEP 2005
- Accepted 3 December 2004
- postoperative analgesia;
- patient-controlled analgesia;
Background : Tramadol is an alternative to other opioids for postoperative pain management. This prospective, randomized, double-blind study was designed to compare the analgesic efficacy of patient-controlled tramadol with patient-controlled morphine for postoperative pain after tonsillectomy in children.
Method : Sixty patients were allocated randomly to receive a patient-controlled analgesia (PCA) with either tramadol (T) or morphine (M), in a double-blind randomized study. When surgery was completed and hemostasis achieved, a standardized loading dose (0.1 mg·kg−1 in group M, or 1 mg·kg−1 in group T) was given. Thereafter, the children helped themselves to bolus doses (morphine (0.02 mg·kg−1) or tramadol (0.2 mg·kg−1) with lockout times of 10 min without time limit via a PCA device. Scores for pain, sedation, nausea, and the bolus and total PCA doses, hemodynamic parameters and side effects were recorded at 5, 15, 30 min and 1, 2, 4, 6 and 24 h during PCA administration.
Results : Pain scores decreased significantly with time in both groups (P < 0.05), but were lower in group M than in group T at 1, 2 and 4 h (P < 0.05). Sedation scores increased with time in both groups (P < 0.05). However there were no significant differences in sedation scores between two groups at any study period, but nausea scores were higher in M group at 4, 6 and 24 h (P < 0.05).
Conclusion : Intravenous patient-controlled tramadol is an alternative to patient-controlled morphine for postoperative pain relief in children after tonsillectomy. Morphine gave better postoperative pain relief, but was associated with a higher incidence of nausea than tramadol.