• physiologic monitoring;
  • bispectral index;
  • child;
  • propofol;
  • opioid;
  • remifentanil


Background : The bispectral (BIS) index is a pharmacodynamic measure of the effect of anesthesia on the central nervous system. The aim of this study was to investigate the relationship between BIS index and predicted plasma concentration of propofol delivered by target controlled infusion (TCI) during emergence in children.

Methods : With approval of IRB, 30 patients (2–7 years) were included in this study. Anesthesia was with TCI propofol 3–5 μg·ml−1 and remifentanil 7.5 ng·ml−1 to maintain BIS 40–60 and the propofol concentration was fixed at 3 μg·ml−1 Remifentanil infusion was stopped 10 min before the end of surgery. BIS values were recorded after reducing propofol in decrement of 0.2 μg·ml−1. BIS values were checked when spontaneous respiration occurred and children were able to obey a command (eye opening or hand grasping).

Results : Spearman's correlation analysis showed negative correlation between BIS and propofol plasma concentration (r = −0.559, P < 0.001). When respiration returned, mean BIS was 77.2 ± 5.3 and propofol plasma concentration 1.6 ± 0.3 μg·ml−1 and when a verbal command was obeyed, BIS was 82.4 ± 5.6 and propofol plasma concentration 1.5 ± 0.3 μg·ml−1.

Conclusions : In preschool children, BIS moderately correlated with the predicted plasma concentration of propofol.