Section Editor: Brian Anderson
Perioperative complications in children with Apert syndrome: a review of 509 anesthetics
Article first published online: 15 NOV 2010
© 2010 Blackwell Publishing Ltd
Volume 21, Issue 1, pages 72–77, January 2011
How to Cite
Barnett, S., Moloney, C. and Bingham, R. (2011), Perioperative complications in children with Apert syndrome: a review of 509 anesthetics. Pediatric Anesthesia, 21: 72–77. doi: 10.1111/j.1460-9592.2010.03457.x
- Issue published online: 14 DEC 2010
- Article first published online: 15 NOV 2010
- Accepted 21 October 2010
- Apert syndrome;
- perioperative complications;
- mid-face hypoplasia;
- obstructive sleep apnoea;
- airway management
Objectives: To perform a retrospective, anesthesia case note review in children with Apert Syndrome.
Aim: To identify perioperative complications in this group of patients.
Background: Apert syndrome is a rare autosomal dominant disorder characterized by craniosynostosis, craniofacial anomalies, and severe symmetrical syndactyly (cutaneous and bony fusion) of the hands and feet. Children with this syndrome require general anesthetics for a number of different operations and procedures. Our institution has records of 71 children with Apert syndrome. Analysis of their general anesthetic records was undertaken, and the incidence of perioperative complications was investigated.
Methods: A retrospective case note review was performed on 61 children with Apert syndrome over a 14-year period. There were a total of 509 general anesthetics administered to these children during this period of time.
Results: There were a total of 31 perioperative respiratory complications occurring in 21 patients (6.1% of the total cases). Twenty-three of these complications were supraglottic airway obstruction (4.5% of total cases).
Conclusions: We found there to be a low incidence of major perioperative major complications in this group of patients. Nevertheless, a significant proportion of these children have obstructive sleep apnoea and may develop supraglottic airway obstruction on induction and emergence from anesthesia due to the associated mid-face anatomical abnormalities.