REVIEW ARTICLE

Local anesthetics and their adjuncts

  1. Jean-Xavier Mazoit1,2

Article first published online: 16 SEP 2011

DOI: 10.1111/j.1460-9592.2011.03692.x

Issue

Pediatric Anesthesia

Pediatric Anesthesia

Volume 22, Issue 1, pages 31–38, January 2012

Additional Information

How to Cite

Mazoit, J.-X. (2012), Local anesthetics and their adjuncts. Pediatric Anesthesia, 22: 31–38. doi: 10.1111/j.1460-9592.2011.03692.x

Author Information

  1. 1

     Département d’Anesthésie-Réanimation, Hôpitaux Universitaires Paris-Sud, AP-HP, Le Kremlin-Bicětre, France

  2. 2

     Laboratoire d’anesthésie INSERM UMR 788, Université Paris Sud, Le Kremlin-Bicêtre, France

*Jean-Xavier Mazoit, Laboratoire d’anesthésie INSERM UMR788, Faculté de Médecine, F-94276 Le Kremlin Bicêtre, Cedex France Email: jean-xavier.mazoit@u-psud.fr

  1. Section Editor: Per-Arne Lonnqvist

Publication History

  1. Issue published online: 1 DEC 2011
  2. Article first published online: 16 SEP 2011
  3. Accepted 5 August 2011
Corrected by:

CORRIGENDUM: Local anesthetics and their adjuncts

Vol. 22, Issue 6, 612, Article first published online: 17 MAY 2012

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Keywords:

  • local anesthetics;
  • pharmacology;
  • regional anesthesia

Summary

Local anesthetics (LA) block propagation of impulses along nerve fibers by inactivation of voltage-gated sodium channels, which initiate action potentials (1). They act on the cytosolic side of phospholipid membranes. Two main chemical compounds are used, amino esters and amino amides. Amino esters are degraded by pseudocholinesterases in plasma. Amino amides are metabolized exclusively by the liver. Only amide LAs will be considered in this article.

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