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Figure S1 Infection matrices.

Figure S2 Histogram of bacterial resistance scores.

Figure S3 Infectivity/resistance against contemporary hosts/phages.

Figure S4 Phenotype frequencies over time.

Figure S5 Rates of infectivity and resistance evolution.

Figure S6 Fluctuating selection over time.

Table S1 Phage genotypes detected during coevolution.

Table S2 dN − dS over time.

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