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Table S1. Relative proportion of matches to the SEED database taxonomic hierarchy.

Table S2. Contribution of phyla level taxonomy to the dissimilarity of confined and unconfined aquifer metagenomes.

Table S3. Relative proportion of matches to a given subsystem hierarchy 1.

Table S4. Contribution of metabolic hierarchical 1 system to the dissimilarity of confined and unconfined aquifer metagenomes.

Table S5. Summary of publicly available metagenomes used in this study.

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