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Fig. S1. Recruitment of inshore ETSP OMZ viromes against Cyanophage P-SSM2 genome from BLASTx comparison (E-value cut-off 10−3) on MG-RAST v.2, showing that the 10 m metagenomic sequences covered most of the genome, whereas at 90 and 200 m only a few well-conserved sequences were identified.

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Table S1a. CRISPR/cas analysis of viromes and reciprocal microbiomes.

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Table S1b. The DNA signature of the CRISPR and spacer region identified in the metagenomes.

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Table S1c. The distribution of the spacer regions in the metagenomes.

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Table S2. Percent of sequences similar to subsystems on MG-RAST by BLASTx (E-value = 10−5, bitscore < 40) with representation in all viromes. Lightest green indicates at < 1% of virome sequences in the subsystem; increasing shades of green indicate < 2%, < 3%, and ≥ 4%. Asterisks indicate the Level 2 subsystems that are represented in all viromes.

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Table S3. Nitrogen metabolism genes and most similar species associated with the gene match from BLASTx comparison of the SEED-nr database on MG-RAST against the surface water, oxycline and anoxic core viromes of the ESP OMZ.

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Table S4. Sulfur metabolism genes and most similar species associated with the gene match from BLASTx comparison of the SEED-nr database on MG-RAST against the surface water, oxycline and anoxic core viromes of the ESP OMZ.

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