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  • Alexander, G., Carlsen, H., and Blomhoff, R. (2003) Strong in vivo activation of NF-kappaB in mouse lenses by classic stressors. Invest Ophthalmol Vis Sci 44: 26832688.
  • Bae, Y.M., and Hastings, J.W. (1994) Cloning, sequencing and expression of dinoflagellate luciferase DNA from a marine alga, Gonyaulax polyedra. Biochim Biophys Acta 1219: 449456.
  • Ballou, B., Fisher, G.W., Hakala, T.R., and Farkas, D.L. (1997) Tumor detection and visualization using cyanine fluorochrome-labeled antibodies. Biotechnol Prog 13: 649658.
  • Ballou, B., Fisher, G.W., Deng, J.S., Hakala, T.R., Srivastava, M., and Farkas, D.L. (1998) Cyanine fluorochrome-labeled antibodies in vivo: assessment of tumor imaging using Cy3, Cy5, Cy5.5, and Cy7. Cancer Detect Prev 22: 251257.
  • Bhaumik, S., and Gambhir, S.S. (2002) Optical imaging of Renilla luciferase reporter gene expression in living mice. Proc Natl Acad Sci USA 99: 377382.
  • BitMansour, A., Burns, S.M., Traver, D., Akashi, K., Contag, C.H., Weissman, I.L., and Brown, J.M. (2002) Myeloid progenitors protect against invasive aspergillosis and Pseudomonas aeruginosa infection following hematopoietic stem cell transplantation. Blood 100: 46604667.
  • Bremer, C., Bredow, S., Mahmood, U., Weissleder, R., and Tung, C.H. (2001) Optical imaging of matrix metalloproteinase-2 activity in tumors: feasibility study in a mouse model. Radiology 221: 523529.
  • Brown, E.B., Campbell, R.B., Tsuzuki, Y., Xu, L., Carmeliet, P., Fukumura, D., and Jain, R.K. (2001) In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy. Nature Med 7: 864868.
  • Burns, S.M., Joh, D., Francis, K.P., Shortliffe, L.D., Gruber, C.A., Contag, P.R., and Contag, C.H. (2001) Revealing the spatiotemporal patterns of bacterial infectious diseases using bioluminescent pathogens and whole body imaging. Contrib Microbiol 9: 7188.
  • Cao, Y.-A., Wagers, A.J., Beilhack, A., Dusich, J., Bachmann, M.H., Negrin, R.S., Weissman, I.L., and Contag, C.H. (2004) Shifting foci of hematopoiesis during reconstitution from single stem cells. Proc Natl Acad Sci USA 101: 221226.
  • Carlsen, H., Moskaug, J.O., Fromm, S.H., and Blomhoff, R. (2002) In vivo imaging of NF-kappa B activity. J Immunol 168: 14411446.
  • Charbonneau, H., Walsh, K.A., McCann, R.O., Prendergast, F.G., Cormier, M.J., and Vanaman, T.C. (1985) Amino acid sequence of the calcium-dependent photoprotein aequorin. Biochemistry 24: 67626771.
  • Cheong, W.F., Prahl, S.A., and Welch, A.J. (1990) A review of the optical properties of biological tissues. IEEE J Quantum Electron 26: 21662185.
  • Christenson, M.A. (2002) Detection systems optimized for low-light chemiluminescence imaging. In Luminescence Technology: Instruments and Applications. Van Dyke, K., Van Dyke, C., and Woodfork, K. (eds). Boca Raton: CRC Press, pp. 469480.
  • Contag, C.H., and Bachmann, M.H. (2002) Advances in in vivo bioluminescence imaging of gene expression. Annu Rev Biomed Eng 4: 235260.
  • Contag, C.H., Contag, P.R., Mullins, J.I., Spilman, S.D., Stevenson, D.K., and Benaron, D.A. (1995) Photonic detection of bacterial pathogens in living hosts. Mol Microbiol 18: 593603.
  • Contag, C.H., Spilman, S.D., Contag, P.R., Oshiro, M., Eames, B., Dennery, P., et al. (1997) Visualizing gene expression in living mammals using a bioluminescent reporter. Photochem Photobiol 66: 523531.
  • Contag, P.R., Olomu, I.N., Stevenson, D.K., and Contag, C.H. (1998) Bioluminescent indicators in living mammals. Nature Med 4: 245247.
  • Conti, E., Franks, N.P., and Brick, P. (1996) Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes. Structure 4: 287298.
  • Cook, S.H., and Griffin, D.E. (2003) Luciferase imaging of a neurotropic viral infection in intact animals. J Virol 77: 53335338.
  • Cormier, M.J., Prasher, D.C., Longiaru, M., and McCann, R.O. (1989) The enzymology and molecular biology of the Ca2+-activated photoprotein, aequorin. Photochem Photobiol 49: 509512.
  • Dionne, P., Caron, M., Labonté, A., Carter-Allen, K., Houle, B., Joly, E., et al. (2002) BRET2: efficient energy transfer from Renilla luciferase to GFP2 to measure protein–protein interactions and intracellular signaling events in live cells. In Luminescence Biotechnology. Van Dyke, K., Van Dyke, C., and Woodfork, K. (eds). Boca Raton: CRC Press, pp. 539555.
  • Frackman, S., Anhalt, M., and Nealson, K.H. (1990) Cloning, organization, and expression of the bioluminescence genes of Xenorhabdus luminescens. J Bacteriol 172: 57675773.
  • Francis, K.P., Joh, D., Bellinger-Kawahara, C., Hawkinson, M.J., Purchio, T.F., and Contag, P.R. (2000) Monitoring bioluminescent Staphylococcus aureus infections in living mice using a novel luxABCDE construct. Infect Immun 68: 35943600.
  • Francis, K.P., Yu, J., Bellinger-Kawahara, C., Joh, D., Hawkinson, M.J., Xiao, G., et al. (2001) Visualizing pneumococcal infections in the lungs of live mice using bioluminescent Streptococcus pneumoniae transformed with a novel gram-positive lux transposon. Infect Immun 69: 33503358.
  • Francis, K.P., Joh, D., Burns, S.M., Gruber, C.A., Contag, C.H., and Contag, P.R. (2002) Whole-body bioluminescent imaging for the study of animal models of human bacterial disease. In Luminescence Biotechnology: Instruments and Applications. Van Dyke, K., Van Dyke, C., and Woodfork, K. (eds). Boca Raton: CRC Press, pp. 517525.
  • Gambhir, S.S. (2002) Molecular imaging of cancer with positron emission tomography. Nature Rev Cancer 2: 683693.
  • Greer, L.F., III, And Szalay, , A.A. (2002) Imaging of light emission from the expression of luciferases in living cells and organisms: a review. Luminescence 17: 4374.
  • Gupta, R.K., Patterson, S.S., Ripp, S., Simpson, M.L., and Sayler, G.S. (2003) Expression of Photorhabdus luminescens lux genes (luxA, B, C, D and E) in Saccharomyces cerevisiae. FEMS Yeast Res 4: 305313.
  • Hamblin, M.R., O'Donnell, D.A., Murthy, N., Contag, C.H., and Hasan, T. (2002) Rapid control of wound infections by targeted photodynamic therapy monitored by in vivo bioluminescence imaging. Photochem Photobiol 75: 5157.
  • Hamblin, M.R., Zahra, T., Contag, C.H., McManus, A.T., and Hasan, T. (2003) Optical monitoring and treatment of potentially lethal wound infections in vivo. J Infect Dis 187: 17171725.
  • Hardy, J., Francis, K.P., DeBoer, M., Chu, P., Gibbs, K., and Contag, C.H. (2004) Extracellular replication of Listeria monocytogenes in the murine gall bladder. Science 303: 851853.
  • Hart, R.C., Matthews, J.C., Hori, K., and Cormier, M.J. (1979) Renilla reniformis bioluminescence: luciferase-catalyzed production of nonradiating excited states from luciferin analogues and elucidation of the excited state species involved in energy transfer to Renilla green fluorescent protein. Biochemistry 18: 22042210.
  • Hastings, J.W. (1996) Chemistries and colors of bioluminescent reactions: a review. Gene 173: 511.
  • Hastings, J.W., and Morin, J.G. (1998) Photons for reporting molecular events: green fluorescent protein and four luciferase systems. In Green Fluorescent Protein: Properties, Applications, and Protocols. Chalfie, M., AndKain, , S. (eds). New York: Wiley-Liss, pp. 1741.
  • Huang, Q., Shan, S., Braun, R.D., Lanzen, J., Anyrhambatla, G., Kong, G., et al. (1999) Noninvasive visualization of tumors in rodent dorsal skin window chambers. Nature Biotechnol 17: 10331035.
  • Inouye, S., Noguchi, M., Sakaki, Y., Takagi, Y., Miyata, T., Iwanaga, S., and Tsuji, F.I. (1985) Cloning and sequence analysis of cDNA for the luminescent protein aequorin. Proc Natl Acad Sci USA 82: 31543158.
  • Inouye, S., Ohmiya, Y., Toya, Y., and Tsuji, F.I. (1992) Imaging of luciferase secretion from transformed Chinese hamster ovary cells. Proc Natl Acad Sci USA 89: 95849587.
  • Kadurugamuwa, J.L., Sin, L.V., Yu, J., Francis, K.P., Kimura, R., Purchio, T., et al. (2003a) Rapid direct method for monitoring antibiotics in a mouse model of bacterial biofilm infection. Antimicrob Agents Chemother 47: 31303137 .
  • Kadurugamuwa, J.L., Sin, L., Albert, E., Yu, J., Francis, K., DeBoer, M., et al. (2003b) Direct continuous method for monitoring biofilm infection in a mouse model. Infect Immun 71: 882890.
  • Kuklin, N.A., Pancari, G.D., Tobery, T.W., Cope, L., Jackson, J., Gill, C., et al. (2003) Real-time monitoring of bacterial infection in vivo: development of bioluminescent staphylococcal foreign-body and deep-thigh-wound mouse infection models. Antimicrob Agents Chemother 47: 27402748.
  • Li, Z., Szittner, R., and Meighen, E.A. (1993) Subunit interactions and the role of the luxA polypeptide in controlling thermal stability and catalytic properties in recombinant luciferase hybrids. Biochim Biophys Acta 1158: 137145.
  • Lipshutz, G.S., Gruber, C.A., Cao, Y., Hardy, J., Contag, C.H., and Gaensler, K.M. (2001) In utero delivery of adeno-associated viral vectors: intraperitoneal gene transfer produces long-term expression. Mol Ther 3: 284292.
  • Liu, J., O'Kane, D.J., and Escher, A. (1997) Secretion of functional Renilla reniformis luciferase by mammalian cells. Gene 203: 141148.
  • Lorenz, W.W., McCann, R.O., Longiaru, M., and Cormier, M.J. (1991) Isolation and expression of a cDNA encoding Renilla reniformis luciferase. Proc Natl Acad Sci USA 88: 44384442.
  • Lorenz, W.W., Cormier, M.J., O'Kane, D.J., Hua, D., Escher, A.A., and Szalay, A.A. (1996) Expression of the Renilla reniformis luciferase gene in mammalian cells. J Biolumin Chemilumin 11: 3137.
  • Luker, G.D., Bardill, J.P., Prior, J.L., Pica, C.M., Piwnica-Worms, D., and Leib, D.A. (2002) Noninvasive bioluminescence imaging of herpes simplex virus type 1 infection and therapy in living mice. J Virol 76: 1214912161.
  • Luker, G.D., Prior, J.L., Song, J., Pica, C.M., and Leib, D.A. (2003) Bioluminescence imaging reveals systemic dissemination of herpes simplex virus type 1 in the absence of interferon receptors. J Virol 77: 1108211093.
  • McCaffrey, A.P., Meuse, L., Pham, T.T., Conklin, D.S., Hannon, G.J., and Kay, M.A. (2002) RNA interference in adult mice. Nature 418: 3839.
  • McCaffrey, A.P., Nakai, H., Pandey, K., Huang, Z., Salazar, F.H., Xu, H., et al. (2003) Inhibition of hepatitis B virus in mice by RNA interference. Nature Biotechnol 21: 639644.
  • McCullers, J.A., and Bartmess, K.C. (2003) Role of neuraminidase in lethal synergism between influenza virus and Streptococcus pneumoniae. J Infect Dis 187: 10001009.
  • McElroy, W.D., and DeLuca, M. (1978) Chemistry of firefly luminescence. In Bioluminescence in Action. Herring, P.J. (ed.). New York: Academic Press, pp. 109128.
  • McElroy, W.D., and DeLuca, M.A. (1983) Firefly and bacterial luminescence: basic science and applications. J Appl Biochem 5: 197209.
  • Maeda, Y., Ueda, H., Hara, T., Kazami, J., Kawano, G., Suzuki, E., and Nagamune, T. (1996) Expression of a bifunctional chimeric protein A-Vargula hilgendorfii luciferase in mammalian cells. Biotechniques 20: 116121.
  • Mahmood, U., Tung, C.H., Bogdanov, A., Jr, and Weissleder, R. (1999) Near-infrared optical imaging of protease activity for tumor detection. Radiology 213: 866870.
  • Mandl, S., Schimmelpfennig, C., Edinger, M., Negrin, R.S., and Contag, C.H. (2002) Understanding immune cell trafficking patterns via in vivo bioluminescence imaging. J Cell Biochem Suppl 39: 239248.
  • Matthews, J.C., Hori, K., and Cormier, M.J. (1977a) Substrate and substrate analogue binding properties of Renilla luciferase. Biochemistry 16: 52175220.
  • Matthews, J.C., Hori, K., and Cormier, M.J. (1977b) Purification and properties of Renilla reniformis luciferase. Biochemistry 16: 8591.
  • Mayerhofer, R., Araki, K., and Szalay, A.A. (1995) Monitoring of spatial expression of firefly luciferase in transformed zebrafish. J Biolumin Chemilumin 10: 271275.
  • Meighen, E.A. (1991) Molecular biology of bacterial bioluminescence. Microbiol Rev 55: 123142.
  • Meighen, E.A. (1993) Bacterial bioluminescence: organization, regulation, and application of the lux genes. FASEB J 7: 10161022.
  • Monack, D.M., Bouley, D.M., and Falkow, S. (2003) Salmonella typhimurium persists within macrophages in the mesenteric lymph nodes of chronically infected Nramp1+/+ mice and can be reactivated by IFNγ neutralization. J Exp Med 199: 231241.
  • Nakajima, A., Seroogy, C.M., Sandora, M.R., Tarner, I.H., Costa, G.L., Taylor-Edwards, C., et al. (2001) Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis. J Clin Invest 107: 12931301.
  • Oshiro, M. (1998) Cooled CCD versus intensified cameras for low-light video – applications and relative advantages. Methods Cell Biol 56: 4562.
  • Padera, T.P., Stoll, B.R., So, P.T.C., and Jain, R.K. (2001) Conventional and high-speed intravital laser scanning microscopy of microvasculature, lymphatics, and leukocyte–endothelial interactions. Mol Imag 1: 915.
  • Park, H.S., Francis, K.P., Yu, J., and Cleary, P.P. (2003) Membranous cells in nasal-associated lymphoid tissue: a portal of entry for the respiratory mucosal pathogen group A streptococcus. J Immunol 171: 25322537.
  • Parsons, S.J., Rhodes, S.A., Connor, H.E., Rees, S., Brown, J., and Giles, H. (2000) Use of a dual firefly and Renilla luciferase reporter gene assay to simultaneously determine drug selectivity at human corticotrophin releasing hormone 1 and 2 receptors. Anal Biochem 281: 187192.
  • Pichler, A., Prior, J.L., and Piwnica-Worms, D. (2003) Imaging reversal of multidrug resistance in living mice with bioluminescence: MDRI P-glycoprotein transports coelenterazine. Proc Natl Acad Sci USA 101: 17021707.
  • Ray, P., Pimenta, H., Paulmurugan, R., Berger, F., Phelps, M.E., Iyer, M., and Gambhir, S.S. (2002) Noninvasive quantitative imaging of protein–protein interactions in living subjects. Proc Natl Acad Sci USA 99: 31053110.
  • Rehemtulla, A., Stegman, L.D., Cardozo, S.J., Gupta, S., Hall, D.E., Contag, C.H., and Ross, B.D. (2000) Rapid and quantitative assessment of cancer treatment response using in vivo bioluminescence imaging. Neoplasia 2: 491495.
  • Rehemtulla, A., Hall, D.E., Stegman, L.D., Chen, G., Bhojani, M.S., Chenevert, T.L., and Ross, B.D. (2002) Molecular imaging of gene expression and efficacy following adenoviral-mediated brain tumor gene therapy. Mol Imag 1: 4355.
  • Rice, B.W., Cable, M.D., and Nelson, M.B. (2001) In vivo imaging of light-emitting probes. J Biomed Opt 6: 432440.
  • Rocchetta, H.L., Boylan, C.J., Foley, J.W., Iversen, P.W., LeTourneau, D.L., McMillian, C.L., et al. (2001) Validation of a noninvasive, real-time imaging technology using bioluminescent Escherichia coli in the neutropenic mouse thigh model of infection. Antimicrob Agents Chemother 45: 129137.
  • Rudin, M., and Weissleder, R. (2003) Molecular imaging in drug discovery and development. Nature Rev Drug Discov 2: 123131.
  • Stables, J., Scott, S., Brown, S., Roelant, C., Burns, D., Lee, M.G., and Rees, S. (1999) Development of a dual glow-signal firefly and Renilla luciferase assay reagent for the analysis of G-protein coupled receptor signalling. J Recept Signal Transduct Res 19: 395410.
  • Sweeney, T.J., Mailander, V., Tucker, A.A., Olomu, A.B., Zhang, W., Cao, Y.-A., Negrin, R.S., and Contag, C.H. (1999) Visualising the kinetics of tumor-cell clearance in living animals. Proc Natl Acad Sci USA 96: 1204412049.
  • Szalay, A.A. (2002) Contributions of light-emitting organisms to cellular and biomedical imaging. In Bioluminescence and Chemiluminescence: Progress and Current Applications. Stanley, P.E., AndKricka, , L.J. (eds). New Jersey: World Scientific, pp. 312.
  • Szittner, R., and Meighen, E. (1990) Nucleotide sequence, expression, and properties of luciferase coded by lux genes from a terrestrial bacterium. J Biol Chem 265: 1658116587.
  • Thompson, E.M., Nagata, S., and Tsuji, F.I. (1989) Cloning and expression of cDNA for the luciferase from the marine ostracod Vargula hilgendorfii. Proc Natl Acad Sci USA 86: 65676571.
  • Thompson, E.M., Nagata, S., and Tsuji, F.I. (1990) Vargula hilgendorfii luciferase: a secreted reporter enzyme for monitoring gene expression in mammalian cells. Gene 96: 257262.
  • Tromberg, B.J., Shah, N., Lanning, R., Cerussi, A., Espinoza, J., Pham, T., et al. (2000) Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy. Neoplasia (New York) 2: 2640.
  • Tuchin, V. (2000) Tissue Optics. Bellingham, WA: SPIE (International Society for Optical Engineering) Press.
  • Tung, C.H., Bredow, S., Mahmood, U., and Weissleder, R. (1999) Preparation of a cathepsin D sensitive near-infrared fluorescence probe for imaging. Bioconjug Chem 10: 892896.
  • Tung, C.H., Mahmood, U., Bredow, S., and Weissleder, R. (2000) In vivo imaging of proteolytic enzyme activity using a novel molecular reporter. Cancer Res 60: 49534958.
  • Valdivia, R.H., and Falkow, S. (1997) Probing bacterial gene expression within host cells. Trends Microbiol 5: 360363.
  • Viviani, V.R., Bechara, E.J., and Ohmiya, Y. (1999) Cloning, sequence analysis, and expression of active Phrixothrix railroad-worms luciferases: relationship between bioluminescence spectra and primary structures. Biochemistry 38: 82718279.
  • Wang, Y., Wang, G., O'Kane, D.J., and Szalay, A.A. (2001) A study of protein–protein interactions in living cells using luminescence resonance energy transfer (LRET) from Renilla luciferase to Aequorea GFP. Mol Gen Genet 264: 578587.
  • Wang, Y., Yu, Y.A., Shabahang, S., Wang, G., and Szalay, A.A. (2002) Renilla luciferase–Aequorea GFP (Ruc-GFP) fusion protein, a novel dual reporter for real-time imaging of gene expression in cell cultures and in live animals. Mol Gen Genet 268: 160168.
  • Ward, W.W. (1985) General aspects of bioluminescence. In Chemi- and Bioluminescence. Burr, J.G. (ed.). New York: Marcel Dekker, pp. 321358.
  • Weissleder, R. (2002) Scaling down imaging: molecular mapping of cancer in mice. Nature Rev Cancer 2: 1118.
  • Weissleder, R., and Ntziachristos, V. (2003) Shedding light onto live molecular targets. Nature Med 9: 123128.
  • Weissleder, R., Tung, C.H., Mahmood, U., and Bogdanov, A., Jr (1999) In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nature Biotechnol 17: 375378.
  • De Wet, J.R., Wood, K.V., Helinski, D.R., and DeLuca, M. (1985) Cloning of firefly luciferase cDNA and the expression of active luciferase in Escherichia coli. Proc Natl Acad Sci USA 82: 78707873.
  • De Wet, J.R., Wood, K.V., DeLuca, M., Helinski, D.R., and Subramani, S. (1987) Firefly luciferase gene: structure and expression in mammalian cells. Mol Cell Biol 7: 725737.
  • Wilson, T., and Hastings, J.W. (1998) Bioluminescence. Annu Rev Cell Dev Biol 14: 197230.
  • Winson, M.K., Swift, S., Hill, P.J., Sims, C.M., Griesmayr, G., Bycroft, B.W., et al. (1998) Engineering the luxCDABE genes from Photorhabdus luminescens to provide a bioluminescent reporter for constitutive and promoter probe plasmids and mini-Tn5 constructs. FEMS Microbiol Lett 163: 193202.
  • Wood, K.V. (1995) The chemical mechanism and evolutionary development of beetle bioluminescence. Photochem Photobiol 62: 662673.
  • Wood, K.V., Lam, Y.A., Seliger, H.H., and McElroy, W.D. (1989a) Complementary DNA coding click beetle luciferases can elicit bioluminescence of different colors. Science 244: 700702.
  • Wood, K.V., Lam, Y.A., McElroy, W.D., and Seliger, H.H. (1989b) Bioluminescent click beetles revisited. J Biolumin Chemilum 4: 3139.
  • Xu, Y., Piston, D.W., and Johnson, C.H. (1999) A bioluminescence resonance energy transfer (BRET) system: application to interacting circadian clock proteins. Proc Natl Acad Sci USA 96: 151156.
  • Xu, Y., Kanauchi, A., Piston, D.W., and Johnson, C.H. (2002) Resonance energy transfer as an emerging technique for monitoring protein–protein interactions in vivo: BRET vs. FRET. In Luminescence Biotechnology. Van Dyke, K., Van Dyke, C., AndWoodfork, , K. (eds). Boca Raton: CRC Press, pp. 529538.
  • Yang, M., Baranov, E., Moossa, A.R., Penman, S., and Hoffman, R.M. (2000a) Visualizing gene expression by whole-body fluorescence imaging. Proc Natl Acad Sci USA 97: 1227812282.
  • Yang, M., Baranov, E., Jiang, P., Sun, F.X., Li, X.M., Li, L., et al. (2000b) Whole-body optical imaging of green fluorescent protein-expressing tumors and metastases. Proc Natl Acad Sci USA 97: 12061211.
  • Yang, M., Baranov, E., Li, X.M., Wang, J.W., Jiang, P., Li, L., et al. (2001) Whole-body and intravital optical imaging of angiogenesis in orthotopically implanted tumors. Proc Natl Acad Sci USA 98: 26162621.
  • Yang, M., Baranov, E., Wang, J.W., Jiang, P., Wang, X., Sun, F.X., et al. (2002) Direct external imaging of nascent cancer, tumor progression, angiogenesis, and metastasis on internal organs in the fluorescent orthotopic model. Proc Natl Acad Sci USA 99: 38243829.
  • Yu, Y.A., and Szalay, A.A. (2002) A Renilla luciferase–Aequorea GFP (ruc-gfp) fusion gene construct permits real-time detection of promoter activation by exogenously administered mifepristone in vivo. Mol Gen Genet 268: 169178.
  • Yu, Y.A., Timiryasova, T., Zhang, Q., Beltz, R., and Szalay, A.A. (2003) Optical imaging: bacteria, viruses, and mammalian cells encoding light-emitting proteins reveal the locations of primary tumors and metastases in animals. Anal Bioanal Chem 377: 964972.
  • Zhang, N., Weber, A., Li, B., Lyons, R., Contag, P.R., Purchio, A.F., and West, D.B. (2003) An inducible nitric oxide synthase-luciferase reporter system for in vivo testing of anti-inflammatory compounds in transgenic mice. J Immunol 170: 63076319.
  • Zhao, M., Yang, M., Baranov, E., Wang, X., Penman, S., Moossa, A.R., and Hoffman, R.M. (2001) Spatial-temporal imaging of bacterial infection and antibiotic response in intact animals. Proc Natl Acad Sci USA 98: 98149818.