Human cardiac inflammatory responses triggered by Coxsackie B viruses are mainly Toll-like receptor (TLR) 8-dependent
Version of Record online: 27 MAY 2005
Volume 7, Issue 8, pages 1117–1126, August 2005
How to Cite
Triantafilou, K., Orthopoulos, G., Vakakis, E., Ahmed, M. A. E., Golenbock, D. T., Lepper, P. M. and Triantafilou, M. (2005), Human cardiac inflammatory responses triggered by Coxsackie B viruses are mainly Toll-like receptor (TLR) 8-dependent. Cellular Microbiology, 7: 1117–1126. doi: 10.1111/j.1462-5822.2005.00537.x
- Issue online: 27 MAY 2005
- Version of Record online: 27 MAY 2005
- Received 30 November, 2004; revised 17 February, 2005; accepted 20 February, 2005.
The group B coxsackieviruses are single-stranded RNA viruses that have been implicated in viral myocarditis. Viral infection of the myocardium, as well as the associated inflammatory response are important determinants of the virus-associated myocardial damage. Although these viruses are known as cytopathic viruses that cause death of the host cell, their viral RNA has been shown to persist in cardiac muscle contributing to a chronic inflammatory cardiomyopathy. Thus, it is essential that we understand the mechanism by which Coxasckie B viruses (CBVs) trigger this inflammatory response. In this study we investigated the involvement of Toll-like receptors (TLRs) in the recognition of CBV virions as well as CBV single-stranded RNA. Here we report that the CBV-induced inflammatory response is mediated through TLR8 and to a lesser extent through TLR7.