Autophagy and antigen presentation
Article first published online: 3 APR 2006
Volume 8, Issue 6, pages 891–898, June 2006
How to Cite
Münz, C. (2006), Autophagy and antigen presentation. Cellular Microbiology, 8: 891–898. doi: 10.1111/j.1462-5822.2006.00714.x
- Issue published online: 3 APR 2006
- Article first published online: 3 APR 2006
- Received 5 December, 2005; revised 5 January, 2006; accepted 12 January, 2006.
CD4+ T cells co-ordinate adaptive immunity and are required for immunological memory establishment and maintenance. They are thought to primarily recognize extracellular antigens, which are endocytosed, processed by lysosomal proteases and then presented on major histocompatibility complex (MHC) class II. However, recent studies have demonstrated that viral, tumour and autoantigens can gain access to this antigen presentation pathway from within cells by autophagy. This review will discuss the autophagic pathways that contribute to endogenous MHC class II antigen processing. Furthermore, potential characteristics of autophagy substrates, qualifying them to access these pathways, and regulation of autophagy will be considered. Finally, I will suggest how antigen presentation after autophagy might contribute to immune surveillance of infected and transformed cells.