Phagocytosis and persistence of Helicobacter pylori
Article first published online: 30 JAN 2007
Volume 9, Issue 4, pages 817–828, April 2007
How to Cite
Allen, L.-A. H. (2007), Phagocytosis and persistence of Helicobacter pylori. Cellular Microbiology, 9: 817–828. doi: 10.1111/j.1462-5822.2007.00906.x
- Issue published online: 30 JAN 2007
- Article first published online: 30 JAN 2007
- Received 31 October, 2006; revised 6 December, 2006; accepted 11 December, 2006.
Helicobacter pylori is a spiral-shaped, flagellated, microaerophilic Gram-negative bacterium that colonizes the gastric epithelium of humans. All persons infected with H. pylori have gastritis, and some will develop severe disease such as peptic ulcers or gastric cancer. A characteristic feature of this infection is the pronounced accumulation of phagocytes, particularly neutrophils, in the gastric mucosa. H. pylori thrives in a phagocyte-rich environment, and we describe here how this organism uses an array of novel virulence factors to manipulate chemotaxis, phagocytosis, membrane trafficking and the respiratory burst as a means to evade elimination by the innate immune response.