Rhoptries are major players in Toxoplasma gondii invasion and host cell interaction
Article first published online: 2 FEB 2007
Volume 9, Issue 4, pages 841–848, April 2007
How to Cite
Dubremetz, J. F. (2007), Rhoptries are major players in Toxoplasma gondii invasion and host cell interaction. Cellular Microbiology, 9: 841–848. doi: 10.1111/j.1462-5822.2007.00909.x
- Issue published online: 2 FEB 2007
- Article first published online: 2 FEB 2007
- Received 2 December, 2006; revised 9 January, 2007; accepted 18 January, 2007.
Rhoptries are unique secretory organelles shared by all Apicomplexan invasive stages. They are exocytosed upon host cell invasion and their contents are involved in creating the moving junction that propels the parasite in the cell and in building the parasitophorous vacuole in which the parasite will develop. In addition, some rhoptry proteins are targeted to the host cell nucleus. The array of roles played by these organelles has considerably expanded in the recent years, making them a major clue to the understanding of the early interaction between these parasites and their host. Yet, our knowledge on these organelles is still very poor and much has to be done before we get a clear view of the part they play in Apicomplexan biology.