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Modelling malaria pathogenesis
Article first published online: 18 JUL 2008
© 2008 The Authors. Journal compilation © 2008 Blackwell Publishing Ltd
Volume 10, Issue 10, pages 1947–1955, October 2008
How to Cite
Mideo, N., Day, T. and Read, A. F. (2008), Modelling malaria pathogenesis. Cellular Microbiology, 10: 1947–1955. doi: 10.1111/j.1462-5822.2008.01208.x
- Issue published online: 8 SEP 2008
- Article first published online: 18 JUL 2008
- Received 1 June, 2008; revised 8 July, 2008; accepted 9 July, 2008.
Almost 20 years after the development of models of malaria pathogenesis began, we are beyond the ‘proof-of-concept’ phase and these models are no longer abstract mathematical exercises. They have refined our knowledge of within-host processes, and have brought insights that could not easily have been obtained from experimentation alone. There is much potential that remains to be realized, however, both in terms of informing the design of interventions and health policy, and in terms of addressing lingering questions about the basic biology of malaria. Recent research has begun to iterate theory and data in a much more comprehensive way, and the use of statistical techniques for model fitting and comparison offers a promising approach for providing a quantitative understanding of the pathogenesis of such a complex disease.