New insights into Chlamydia intracellular survival mechanisms

Authors


*E-mail valdi001@mc.duke.edu; Tel. (+1) 919 681 3831; Fax (+1) 919 681 9193.

Summary

Chlamydia sp. are responsible for a wide range of diseases of significant clinical and public health importance. In this review, we highlight how recent cellular and functional genomic approaches have significantly increased our knowledge of the pathogenic mechanisms used by these genetically intractable bacteria. As the extensive repertoire of chlamydial proteins that are translocated into the mammalian host is identified and characterized, a molecular understanding of how Chlamydiae co-opt host cellular functions and block innate immune pathways is beginning to emerge.

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