New insights into Chlamydia intracellular survival mechanisms
Article first published online: 5 AUG 2009
© 2009 Blackwell Publishing Ltd
Volume 11, Issue 11, pages 1571–1578, November 2009
How to Cite
Cocchiaro, J. L. and Valdivia, R. H. (2009), New insights into Chlamydia intracellular survival mechanisms. Cellular Microbiology, 11: 1571–1578. doi: 10.1111/j.1462-5822.2009.01364.x
- Issue published online: 8 OCT 2009
- Article first published online: 5 AUG 2009
- Received 11 June, 2009; revised 16 July, 2009; accepted 20 July, 2009.
Chlamydia sp. are responsible for a wide range of diseases of significant clinical and public health importance. In this review, we highlight how recent cellular and functional genomic approaches have significantly increased our knowledge of the pathogenic mechanisms used by these genetically intractable bacteria. As the extensive repertoire of chlamydial proteins that are translocated into the mammalian host is identified and characterized, a molecular understanding of how Chlamydiae co-opt host cellular functions and block innate immune pathways is beginning to emerge.