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Salmonella – the ultimate insider. Salmonella virulence factors that modulate intracellular survival
Article first published online: 23 SEP 2009
© Published 2009. This article is a US Government work and is in the public domain in the USA
Volume 11, Issue 11, pages 1579–1586, November 2009
How to Cite
Ibarra, J. A. and Steele-Mortimer, O. (2009), Salmonella – the ultimate insider. Salmonella virulence factors that modulate intracellular survival. Cellular Microbiology, 11: 1579–1586. doi: 10.1111/j.1462-5822.2009.01368.x
- Issue published online: 8 OCT 2009
- Article first published online: 23 SEP 2009
- Received 11 June, 2009; revised 23 July, 2009; accepted 27 July, 2009.
Salmonella enterica serovar Typhimurium is a common facultative intracellular pathogen that causes food-borne gastroenteritis in millions of people worldwide. Intracellular survival and replication are important virulence determinants and the bacteria can be found in a variety of phagocytic and non-phagocytic cells in vivo. Invasion of host cells and intracellular survival are dependent on two type III secretion systems, T3SS1 and T3SS2, each of which translocates a distinct set of effector proteins. However, other virulence factors including ion transporters, superoxide dismutase, flagella and fimbriae are also involved in accessing and utilizing the intracellular niche.