These authors contributed equally to this work.
The bacterial second messenger c-di-GMP: mechanisms of signalling
Article first published online: 24 JUN 2011
© 2011 Blackwell Publishing Ltd
Volume 13, Issue 8, pages 1122–1129, August 2011
How to Cite
Mills, E., Pultz, I. S., Kulasekara, H. D. and Miller, S. I. (2011), The bacterial second messenger c-di-GMP: mechanisms of signalling. Cellular Microbiology, 13: 1122–1129. doi: 10.1111/j.1462-5822.2011.01619.x
- Issue published online: 18 JUL 2011
- Article first published online: 24 JUN 2011
- Received 13 April, 2011; revised 9 May, 2011; accepted 11 May, 2011.
Cyclic-di-GMP (c-di-GMP) regulates many important bacterial processes. Freely diffusible intracellular c-di-GMP is determined by the action of metabolizing enzymes that allow integration of numerous input signals. c-di-GMP specifically regulates multiple cellular processes by binding to diverse target molecules. This review highlights important questions in research into the mechanisms of c-di-GMP signalling and its role in bacterial physiology.