Eating the strangers within: host control of intracellular bacteria via xenophagy
Article first published online: 10 JUL 2011
Published 2011. This article is a US Government work and is in the public domain in the USA
Volume 13, Issue 9, pages 1319–1327, September 2011
How to Cite
Knodler, L. A. and Celli, J. (2011), Eating the strangers within: host control of intracellular bacteria via xenophagy. Cellular Microbiology, 13: 1319–1327. doi: 10.1111/j.1462-5822.2011.01632.x
- Issue published online: 17 AUG 2011
- Article first published online: 10 JUL 2011
- Received 29 April, 2011; revised 26 May, 2011; accepted 31 May, 2011.
Many bacterial pathogens rely on an intracellular cycle to ensure their proliferation within infected hosts, through their ability to avoid or circumvent host bactericidal pathways. Recent evidence supports an increasingly important role for the autophagy pathway in innate immune defences against intracellular pathogens, as a mechanism of capture of either cytosol-adapted or vacuolar bacteria that redirect them to the lysosomal compartment for killing. Antibacterial autophagy, also referred to as xenophagy, involves selective recognition of intracellular bacteria and their targeting to the autophagic machinery for degradation. Here we review recent advances in our molecular understanding of these processes, and in how bacteria have adapted to avoid xenophagy or even take advantage of this innate immune process.