The role of the spleen in malaria

Authors


E-mail hernandoa.delportillo@cresib.cat; Tel. (+34) 690 737 229; Fax (+34) 933 129 410.

Summary

The spleen is a complex organ that is perfectly adapted to selectively filtering and destroying senescent red blood cells (RBCs), infectious microorganisms and Plasmodium-parasitized RBCs. Infection by malaria is the most common cause of spleen rupture and splenomegaly, albeit variably, a landmark of malaria infection. Here, the role of the spleen in malaria is reviewed with special emphasis in lessons learned from human infections and mouse models.

Ancillary