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Review of biomarkers in colorectal cancer

Authors


Miss K. F. Newton, Department of Medical Genetics, 6th Floor, St Mary’s Hospital, Central Manchester University Hospitals Trust, Oxford Road, Manchester M13 9WL, UK.
E-mail: Katynewton2002@yahoo.co.uk

Abstract

Aim  Advances in molecular technology have resulted in the discovery of many putative biomarkers relevant to colorectal cancer (CRC).

Method  Literature searches were performed on PubMed and EMBASE using the words ‘colorectal cancer’, AND ‘biomarkers OR markers’. Biomarkers that are either currently in clinical use or have potential clinical use were identified.

Results  Most potential markers are in the discovery phase waiting to undergo clinical validation. Hypermethylation of the plasma septin-9 gene shows promise as a nonstool-based screening tool. Hypermethylation of the DYPD gene (encodes the enzyme dihydropyrimidine dehydrogenase) and variation of the uridine diphosphate-glucuronosyltransferase 1A (UGT1A1) gene have predictive value for side effects and the efficacy of 5-fluoruracil and irinotecan, respectively. Mismatch repair protein immunohistochemistry is able to predict response to 5-fluorouracil, and the KRAS (Kirsten rat sarcoma viral oncogene) and B-RAF (v-RAF murine sarcoma viral oncogene homolog B1) somatic gene mutation status can predict the response to anti-epidermal growth factor receptor therapy.

Conclusion  Recent advances indicate that the widespread use of biomarkers may herald the next major advance in the diagnosis and management of CRC.

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