Trends in incidence, treatment and survival of patients with stage IV colorectal cancer: a population-based series
Article first published online: 7 DEC 2011
© 2011 The Authors. Colorectal Disease © 2011 The Association of Coloproctology of Great Britain and Ireland
Volume 14, Issue 1, pages 56–61, January 2012
How to Cite
van der Pool, A. E. M., Damhuis, R. A., IJzermans, J. N. M., de Wilt, J. H. W., Eggermont, A. M. M., Kranse, R. and Verhoef, C. (2012), Trends in incidence, treatment and survival of patients with stage IV colorectal cancer: a population-based series. Colorectal Disease, 14: 56–61. doi: 10.1111/j.1463-1318.2010.02539.x
- Issue published online: 7 DEC 2011
- Article first published online: 7 DEC 2011
- Accepted manuscript online: 22 DEC 2010 12:13PM EST
- Received 1 July 2010; accepted 15 November 2010; Accepted Article online 22 December 2010
- gastrointestinal surgery;
- hepatic surgery;
- surgical oncology
Aim The incidence, patterns of care and survival were determined in patients with stage IV colorectal cancer (CRC) in a population-based series.
Method Computer records for patients diagnosed with stage IV CRC diagnosed from 1 January 1995 to 31 December 2007 were retrieved from the Rotterdam Cancer Registry. Surgical resection of the primary tumour, chemotherapy use, hepatic surgery and survival were evaluated according to year of diagnosis, age, gender and primary tumour site.
Results In the southwestern part of the Netherlands, 19 014 new patients with CRC were diagnosed and synchronous metastatic disease was found in 3482 (18%). This proportion increased during the study period, from 16% to 21%. Surgical resection of the primary tumour was performed in approximately 50% of the patients and did not change over time. Postoperative 30-day mortality was 8%. Chemotherapy use increased from 18% in the first period to 56% in the latest period. Liver surgery increased from 4% in the first period to 10% in the latest period. Median survival increased from 7 months to 12 months and 2-year survival increased from 14% to 28%. Two-year survival declined with increasing age and was significantly worse for right-sided tumours (14%).
Conclusion Survival of patients with stage IV CRC has improved over time and this is probably a result of the increased use of chemotherapy and the increased numbers of patients who underwent hepatic surgery.