Diagnostic accuracy of narrow-band imaging for the differentiation of neoplastic from non-neoplastic colorectal polyps: a meta-analysis
Article first published online: 20 DEC 2012
© 2012 The Authors. Colorectal Disease © 2012 The Association of Coloproctology of Great Britain and Ireland
Volume 15, Issue 1, pages 3–11, January 2013
How to Cite
Wu, L., Li, Y., Li, Z., Cao, Y. and Gao, F. (2013), Diagnostic accuracy of narrow-band imaging for the differentiation of neoplastic from non-neoplastic colorectal polyps: a meta-analysis. Colorectal Disease, 15: 3–11. doi: 10.1111/j.1463-1318.2012.02947.x
- Issue published online: 20 DEC 2012
- Article first published online: 20 DEC 2012
- Accepted manuscript online: 17 JAN 2012 05:30PM EST
- Received 22 October 2010; accepted 20 December 2010; Accepted Article online 17 January 2012
- Narrow-band imaging;
- neoplastic lesions;
Aim Narrow-band imaging (NBI) is a novel imaging technology that makes the superficial vasculature of gastrointestinal mucosa visible. However, the real accuracy for the differentiation of neoplastic from non-neoplastic polyps by NBI for the colorectum is still unknown.
Method A meta-analysis was carried out of studies which assessed the precision of NBI in the diagnosis of colorectal neoplastic polyps. Searches included PubMed and Embase and two reviewers independently assessed their quality with a modified version of the quadas and stard tools. The study pooled estimates of sensitivity, specificity, diagnostic odds ratio (DOR) and area under the curve (AUC).
Results There were 11 relevant original papers which fulfilled the inclusion criteria. The pooled sensitivity and specificity were 0.92 (95% CI 0.90–0.93) and 0.83 (95% CI 0.81–0.86) respectively. The AUC for NBI was 0.95 [SE 0.01; DOR 53.72 (95% CI 35.66–80.92)]. The sensitivity and specificity were 0.92 (95% CI 0.90–0.94) and 0.81 (95% CI 0.78–0.84) with magnification, and 0.91 (95% CI 0.88–0.93) and 0.86 (95% CI 0.82–0.89) without magnification. For the mucosal pattern sensitivity and specificity were 0.90 (95% CI 0.85–0.940) and 0.88 (95% CI 0.82–0.93), and for vascular pattern intensity they were 0.92 (95% CI 0.90–0.94) and 0.88 (95% CI 0.83–0.91).
Conclusion Narrow-band imaging, with or without magnification, has a high diagnostic precision for colorectal neoplastic polyps using either vascular pattern intensity or mucosal pattern assessment as the measure.