Preliminary data of the present study were presented at the 17th Union European Gastroenterological Week (November 2009, London).
Impact of family history of gastric cancer on colorectal neoplasias in young Japanese
Version of Record online: 20 DEC 2012
© 2012 The Authors. Colorectal Disease © 2012 The Association of Coloproctology of Great Britain and Ireland
Volume 15, Issue 1, pages 42–46, January 2013
How to Cite
Hata, K., Shinozaki, M., Toyoshima, O., Toyoshima, A., Matsumoto, S., Saisho, T. and Tsurita, G. (2013), Impact of family history of gastric cancer on colorectal neoplasias in young Japanese. Colorectal Disease, 15: 42–46. doi: 10.1111/j.1463-1318.2012.03108.x
- Issue online: 20 DEC 2012
- Version of Record online: 20 DEC 2012
- Accepted manuscript online: 29 MAY 2012 10:08AM EST
- Received 27 November 2011; accepted 16 February 2012; Accepted Article online 29 May 2012
- Colorectal neoplasia;
- family member;
- gastric cancer;
- Lynch syndrome;
- risk factor
Aim The aim of this study was to elucidate risk factors for the development of colorectal neoplasia in the young population. In particular, we focused on the family history of gastric cancer.
Method Young Japanese subjects aged 30–49 years old who underwent colonoscopy for the first time from August 2007 to August 2008 were included in this study. A total of 300 unselected consecutive patients (mean age 40.5 years) were eligible for analysis, and family history of colorectal cancer and gastric cancer, sex, age, body mass index, positivity of faecal occult blood test and the presence of symptoms were evaluated. Risk factors for developing colorectal adenoma and/or carcinoma were assessed.
Results Colorectal neoplasias were detected in 83 (27.7%) cases. Two were found to have invasive carcinoma. Univariate and multivariate analyses revealed that family history of gastric cancer (OR 2.09, 95% CI 1.12–3.92, P = 0.02) was an independent risk factor for the development of colorectal neoplasia, as well as male sex (OR 1.89, 95% CI 1.10–3.27, P = 0.02), older age (OR 2.05, 95% CI 1.18–3.55, P = 0.01) and positive faecal occult blood test (OR 1.99, 95% CI 1.14–3.48, P = 0.02).
Conclusion In the young population under 50 years of age, a family history of gastric cancer is an independent risk factor for the development of colorectal neoplasia.