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Effect of local gentamicin–collagen on perineal wound complications and cancer recurrence after abdominoperineal resection: a multicentre randomized controlled trial



This article is corrected by:

  1. Errata: Erratum Volume 16, Issue 3, 228–229, Article first published online: 12 February 2014

Åsa Collin, Department of Surgical Science, Uppsala University, 751 85 Uppsala, Sweden.


Aim  Perineal wound sepsis is a common problem after abdominoperineal resection of the rectum (APR), with a reported incidence of 10–15% in previously non-irradiated patients, 20–30% in patients given preoperative radiation and 50% among patients submitted to preoperative radiation combined with chemotherapy. The local application of gentamicin–collagen was evaluated to determine whether its use in the perineal wound reduced risk complications and had an effect on cancer recurrence.

Method  In this prospective multicentre (seven hospitals) randomized controlled trial, 102 patients undergoing APR due to cancer or benign disease were randomized into two groups including surgery with gentamicin–collagen (GS+, = 52) or surgery without gentamicin–collagen (GS−, = 50). Patients were followed at 7, 30 and 90 days and at 1 and 5 years.

Results  There were no statistically significant differences between the two groups regarding perineal wound complications, infectious or non-infectious, or cancer recurrence.

Conclusion  There was no statistically significant effect on perineal wound complications or cancer recurrence following the local administration of gentamicin–collagen during APR.